While there has been a recent upsurge of research in other anxiety disorders, social phobia has been neglected. The few pharmacological trials involving social phobics are uninterpretable because of small N's, inadequate dosages, lack of uniform or specified diagnostic criteria, and most important, a tendency to study mixed phobic populations and not seprately report social phobic outcome. Also, epidemological, familial and biological challenge studies of social phobia are entirely lacking. The existing literature and our preliminary data both suggest the following: Social phobia seriously impairs work and social functioning, and is associated with several secondary psychiatric syndromes, especially alcohol abuse. Social phobia may be dramatically responsive to MAO inhibitors and beta adrenergic blockers. Demographic, clinical and psychobiological data suggest patients who meet DSM-III criteria for social phobia (primary social phobics) are distinct from panic disorder or agoraphobic patients, many of whom develop secondary social phobic features. Within primary social phobia, patients with specific limited social fears (i.e. public speaking) may differ from those with more generalized pervasive social anxiety. We propose a placebo controlled evaluation of the MAOI phenelzine and the beta bocker atenolol in 90 DSM-III social phobics, to be carried out over 4 years. Eighty panic disorder or agoraphobic patients with secondary social phobic features will be studied as a comparison group. Responders and partial responders to acute treatment will enter a maintenance phase. Responders to phenelzine or atenolol in the maintenance phase will enter a placebo controlled discontinuation phase. Patients will also undergo lactate and other biological challenges and family study as part of already funded studies. Various patient subtypes will be compared in terms of treatment response and other parameters. The clinical significance of this program is to test the efficacy of two promising treatments for various subtypes of social phobia. The theoretical significance lies in the fact that controlled data will be provided on the contribution of clinical subtype, presence or absence of panic attacks and initial level of depression to response of socially anxious patients to MAOIs and beta blockers.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH040121-02
Application #
3378090
Study Section
(SRC)
Project Start
1984-09-20
Project End
1988-08-31
Budget Start
1985-09-01
Budget End
1986-08-31
Support Year
2
Fiscal Year
1985
Total Cost
Indirect Cost
Name
New York State Psychiatric Institute
Department
Type
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
Cohen, Jonah N; Potter, Carrie M; Drabick, Deborah A G et al. (2015) Clinical presentation and pharmacotherapy response in social anxiety disorder: The effect of etiological beliefs. Psychiatry Res 228:65-71
Bruce, Laura C; Heimberg, Richard G; Blanco, Carlos et al. (2012) Childhood maltreatment and social anxiety disorder: implications for symptom severity and response to pharmacotherapy. Depress Anxiety 29:131-8
Liebowitz, M R; Schneier, F; Gitow, A et al. (1993) Reversible monoamine oxidase-A inhibitors in social phobia. Clin Neuropharmacol 16 Suppl 2:S83-8
Liebowitz, M R; Gorman, J M; Fyer, A J et al. (1988) Pharmacotherapy of social phobia: an interim report of a placebo-controlled comparison of phenelzine and atenolol. J Clin Psychiatry 49:252-7
Liebowitz, M R; Campeas, R; Levin, A et al. (1987) Pharmacotherapy of social phobia. A condition distinct from panic attacks. Psychosomatics 28:305-8