This is a revision of the competing continuation of R01-MH43454. This application seeks five additional years of support to continue the PI's research program on the neural substrates of affective style and emotion regulation. Individual differences in affective style and emotion regulation determine variation in stress responsivity and vulnerability to mood, anxiety and externalizing disorders. The broad goal of this application is to further understand the neural circuitry underlying individual differences in emotion regulation and to determine the relation between the neural bases and biobehavioral correlates of voluntary and automatic forms of the regulation of negative and positive affect. Work is proposed that also extends this work to late adolescents who are part of a longitudinal sample that we have been following with imaging and behavioral measures for the past 5 years and on whom we have behavioral and hormonal data since birth. One major study will examine relations between voluntary and automatic regulation of both negative and positive emotion to determine if skill in one predicts skill in the others, and to determine if there is overlapping or orthogonal neural substrates of each, including activation and connectivity measures. We will specifically address the question of whether participants who are skilled at down-regulating negative affect are also skilled at upregulating positive affect. As part of this study, we will also examine relations between the regulation of picture-induced negative affect and thermal pain-induced negative affect. Another study will examine relations between individual differences in working memory (WM) capacity and emotion regulation. In addition to tasks assessing emotion regulation, participants will be given a working memory task (n-back) in the scanner and activated regions of overlap in the prefrontal cortex during the WM and emotion regulation tasks will be determined. In addition, we will examine relations between working memory capacity and automatic and voluntary emotion regulation. Finally, using a sample derived from the Wisconsin Study of Families and Work, we will examine relations between individual differences in emotion regulation and symptoms and diagnoses of psychopathology. We will also relate neural and psychophysiological measures of emotion regulation to the longitudinal corpus of data already collected on these participants. This work will provide critical new information on the neurobiology of affective style. These new data will further our understanding of endophenotypes of affective processing that are associated with vulnerability to psychopathology.

Public Health Relevance

Vulnerability to mood and anxiety disorders appears to be at least in part determined by a person's capacity to regulate his or her emotions. The ability to recover following a negative event and to reappraise a situation to make it less threatening is of great benefit in adaptively responding to the environment. This project is focused on identifying the brain mechanisms that determine our ability to regulate our emotions, both to down-regulate our negative emotions and to upregulate our positive emotions. This work has significant implications for developing new psychological and pharmacological treatments for mood and anxiety disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH043454-25
Application #
8582072
Study Section
Biobehavioral Mechanisms of Emotion, Stress and Health Study Section (MESH)
Program Officer
Kozak, Michael J
Project Start
1989-02-01
Project End
2016-11-30
Budget Start
2013-12-27
Budget End
2014-11-30
Support Year
25
Fiscal Year
2014
Total Cost
$511,157
Indirect Cost
$167,652
Name
University of Wisconsin Madison
Department
Pediatrics
Type
Other Domestic Higher Education
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Lapate, Regina C; Samaha, Jason; Rokers, Bas et al. (2017) Inhibition of Lateral Prefrontal Cortex Produces Emotionally Biased First Impressions: A Transcranial Magnetic Stimulation and Electroencephalography Study. Psychol Sci 28:942-953
Hanson, Jamie L; van den Bos, Wouter; Roeber, Barbara J et al. (2017) Early adversity and learning: implications for typical and atypical behavioral development. J Child Psychol Psychiatry 58:770-778
Korponay, Cole; Dentico, Daniela; Kral, Tammi et al. (2017) Neurobiological correlates of impulsivity in healthy adults: Lower prefrontal gray matter volume and spontaneous eye-blink rate but greater resting-state functional connectivity in basal ganglia-thalamo-cortical circuitry. Neuroimage 157:288-296
Lapate, R C; Rokers, B; Tromp, D P M et al. (2016) Awareness of Emotional Stimuli Determines the Behavioral Consequences of Amygdala Activation and Amygdala-Prefrontal Connectivity. Sci Rep 6:25826
Grupe, D W; Wielgosz, J; Davidson, R J et al. (2016) Neurobiological correlates of distinct post-traumatic stress disorder symptom profiles during threat anticipation in combat veterans. Psychol Med 46:1885-95
Dentico, Daniela; Ferrarelli, Fabio; Riedner, Brady A et al. (2016) Short Meditation Trainings Enhance Non-REM Sleep Low-Frequency Oscillations. PLoS One 11:e0148961
Salomons, Tim V; Nusslock, Robin; Detloff, Allison et al. (2015) Neural emotion regulation circuitry underlying anxiolytic effects of perceived control over pain. J Cogn Neurosci 27:222-33
Pasha Hosseinbor, A; Chung, Moo K; Koay, Cheng Guan et al. (2015) 4D hyperspherical harmonic (HyperSPHARM) representation of surface anatomy: a holistic treatment of multiple disconnected anatomical structures. Med Image Anal 22:89-101
Heller, Aaron S; Fox, Andrew S; Wing, Erik K et al. (2015) The Neurodynamics of Affect in the Laboratory Predicts Persistence of Real-World Emotional Responses. J Neurosci 35:10503-9
Hanson, Jamie L; Nacewicz, Brendon M; Sutterer, Matthew J et al. (2015) Behavioral problems after early life stress: contributions of the hippocampus and amygdala. Biol Psychiatry 77:314-23

Showing the most recent 10 out of 139 publications