There have been a growing number of reports associating schizophrenia with lateralized pathology in the brain, in most cases implicating dysfunction in the left hemisphere. Studies reporting hemispheric asymmetries in schizophrenia have utilized diverse methodologies, including magnetic resonance imaging, positron emission tomography, neuropathology and chemopathology, motor assessments, event-related potentials, and neuropsychological assessments. There is a smaller body of literature regarding lateralized pathology in bipolar disorder, which suggests that there may be greater right than left hemisphere involvement in this condition. Because findings related to hemispheric asymmetry are among the most commonly reported psychobiological findings in schizophrenia with localizing value, we considered that laterality assessments may be associated with psychopathological symptoms and illness outcome (quality of life) as well. Further, because some investigators have theorized that schizophrenia and bipolar illness may in fact be closely related, we considered that measures of laterality may also shed light on the relationship of these two conditions, with schizophrenia being associated with greater left hemisphere impairment, and bipolar disorder with greater right hemisphere impairment. We have recently completed studies of upper extremity motor instability which support this idea. In the current proposal we plan to assess patients with schizophrenia, bipolar disorder, and healthy comparison subjects to determine if these groups differ from each other on measures of lateralized function over a six month interval. Measures include L and R motor, sensory, and cognitive function (hand force instability and rigidity, dichotic listening, Warrington Recognition Memory Test Posner Test, verbal and figural fluency Consonant-Vowel-Consonant Test, Chair Identification Test), and brain function (functional MRI). We also plan to determine if these same measures relate to the positive psychotic symptoms, manic symptoms, and illness outcome as reflected in a measure of quality of life (Quality of Well Being Scale). The longitudinal nature of the study allows us to address important trait and state issues. We hope these studies will provide insights into the localization of pathology in schizophrenia and bipolar disorder, as well as their relationship to each other.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Research Project (R01)
Project #
Application #
Study Section
Special Emphasis Panel (ZMH1-CRB-O (01))
Program Officer
Heinssen, Robert K
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Veterans Medical Research Fdn/San Diego
San Diego
United States
Zip Code
Lohr, James B; May, Todd; Caligiuri, Michael P (2013) Quantitative assessment of motor abnormalities in untreated patients with major depressive disorder. J Affect Disord 146:84-90
Brown, Gregory G; Lee, Jun-Seok; Strigo, Irina A et al. (2011) Voxel-based morphometry of patients with schizophrenia or bipolar I disorder: a matched control study. Psychiatry Res 194:149-56
Brown, Gregory G; Lohr, James; Notestine, Randy et al. (2007) Performance of schizophrenia and bipolar patients on verbal and figural working memory tasks. J Abnorm Psychol 116:741-53
Lohr, James B; Hellige, Joseph B; Cherry, Barbara J et al. (2006) Impaired hemispheric communication in schizophrenia: a study using the consonant-vowel-consonant task. Schizophr Res 87:279-88
Lohr, James B; Caligiuri, Michael P (2006) Abnormalities in motor physiology in bipolar disorder. J Neuropsychiatry Clin Neurosci 18:342-9
Caligiuri, Michael P; Brown, Gregory G; Meloy, M J et al. (2006) Striatopallidal regulation of affect in bipolar disorder. J Affect Disord 91:235-42
Caligiuri, Michael P; Hellige, Joseph B; Cherry, Barbara J et al. (2005) Lateralized cognitive dysfunction and psychotic symptoms in schizophrenia. Schizophr Res 80:151-61
Brown, Gregory G; Caligiuri, Michael; Meloy, M J et al. (2004) Functional brain asymmetries during visuomotor tracking. J Clin Exp Neuropsychol 26:356-68
Caligiuri, Michael P; Brown, Gregory G; Meloy, M J et al. (2004) A functional magnetic resonance imaging study of cortical asymmetry in bipolar disorder. Bipolar Disord 6:183-96
Caligiuri, Michael P; Brown, Gregory G; Meloy, M J et al. (2003) An fMRI study of affective state and medication on cortical and subcortical brain regions during motor performance in bipolar disorder. Psychiatry Res 123:171-82