This competing renewal will provide continuing support for the Syntheses of HIV/AIDS Research Project (SHARP). The studies will center on issues central to factors that underlie the efficacy of HIV risk-reduction interventions, with a series of studies conducted for each of three interrelated specific aims related to intervention content, maintenance of risk behavior change, and structural interventions for HIV prevention. First, intensive, psychosocial behavioral interventions will be content-analyzed across a broad set of HIV prevention studies and these dimensions will be related to the trials'efficacy. Structural aspects integrated into individual trials will also be evaluated. These results will inform not only key content dimensions but also highlight improvements to reporting requirements of future intervention trials. Second, theory-driven meta-analyses will examine how sexual risk-behavior change can best be maintained and with what success sexual infections are averted, focusing in turn on adolescents, heterosexual women, men who have sex with men, and African-Americans;each of these will consider the role of supportive social milieus in facilitating or hindering efficacy. Moreover, some will examine prevention across populations and the roles of HIV knowledge and levels of protected sexual interactions at the outset of trials. Third, meta-analyses will be performed of the literatures relating to prevention of HIV through changes in social and policy structure that affect the availability of preventative actions, including condom availability and condom-use policies needle exchange programs, and increases in services for sexually transmitted infections. By carefully summing up the evidence to date on these important and quickly growing literatures, these meta-analyses will inform public health officials, community-based interventionists, and scientists about which interventions work best, which components of interventions have the largest impact, and the circumstances under which HIV risk-reduction interventions are most likely to be produce lasting change.

Public Health Relevance

This proposal, Syntheses of HIV Prevention Research, Phase III, has extremely high relevance to public health in that its studies review, summarize, and organize the voluminous available scientific evidence regarding the best intervention techniques to prevent the spread of HIV among the population, which is a highly important public health goal. The proposal best matches PA-07-070, "Research Project Grant (Parent R01)." Although aspects of the planned investigation are relevant to other program announcements, the best match was deemed to be investigator-initiated as the goals of the investigation are broader than any particular program announcement.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH058563-14
Application #
8266029
Study Section
Behavioral and Social Science Approaches to Preventing HIV/AIDS Study Section (BSPH)
Program Officer
Kamath, Susannah M Allison
Project Start
1998-09-10
Project End
2014-02-28
Budget Start
2012-03-01
Budget End
2013-02-28
Support Year
14
Fiscal Year
2012
Total Cost
$524,369
Indirect Cost
$143,988
Name
University of Connecticut
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
614209054
City
Storrs-Mansfield
State
CT
Country
United States
Zip Code
06269
Finitsis, David J; Pellowski, Jennifer A; Johnson, Blair T (2014) Text message intervention designs to promote adherence to antiretroviral therapy (ART): a meta-analysis of randomized controlled trials. PLoS One 9:e88166
Johnson, Blair T; Michie, Susan; Snyder, Leslie B (2014) Effects of behavioral intervention content on HIV prevention outcomes: a meta-review of meta-analyses. J Acquir Immune Defic Syndr 66 Suppl 3:S259-70
LaCroix, Jessica M; Snyder, Leslie B; Huedo-Medina, Tania B et al. (2014) Effectiveness of mass media interventions for HIV prevention, 1986-2013: a meta-analysis. J Acquir Immune Defic Syndr 66 Suppl 3:S329-40
Protogerou, Cleo; Johnson, Blair T (2014) Factors underlying the success of behavioral HIV-prevention interventions for adolescents: a meta-review. AIDS Behav 18:1847-63
Reid, Allecia E; Dovidio, John F; Ballester, Estrellita et al. (2014) HIV prevention interventions to reduce sexual risk for African Americans: the influence of community-level stigma and psychological processes. Soc Sci Med 103:118-25
Abraham, Charles; Johnson, Blair T; de Bruin, Marijn et al. (2014) Enhancing reporting of behavior change intervention evaluations. J Acquir Immune Defic Syndr 66 Suppl 3:S293-9
Kaufman, Michelle R; Cornish, Flora; Zimmerman, Rick S et al. (2014) Health behavior change models for HIV prevention and AIDS care: practical recommendations for a multi-level approach. J Acquir Immune Defic Syndr 66 Suppl 3:S250-8
LaCroix, Jessica M; Pellowski, Jennifer A; Lennon, Carter A et al. (2013) Behavioural interventions to reduce sexual risk for HIV in heterosexual couples: a meta-analysis. Sex Transm Infect 89:620-7
Lennon, Carter A; Huedo-Medina, Tania B; Gerwien, Daniel P et al. (2012) A role for depression in sexual risk reduction for women? A meta-analysis of HIV prevention trials with depression outcomes. Soc Sci Med 75:688-98
Ferrer, Rebecca A; Huedo-Medina, Tania B; Johnson, Blair T et al. (2011) Exercise interventions for cancer survivors: a meta-analysis of quality of life outcomes. Ann Behav Med 41:32-47

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