Using the resources of an epidemiologically defined, longitudinal twin study, we examine developmental course and biopsychosocial risks for childhood psychopathology. Building on existing screening at ages 2 and 7 years, we characterize risk factors at ages 2, 7, and 12 relevant to the development of internalizing (anxiety and depression), externalizing (oppositional and conduct disorder), and ADHD. Most of our at-risk cases qualify for a DSM-IV diagnosis, yet we include individuals with sub-threshold symptoms and a large control group.
Specific aims i nclude characterization of risk factors, analysis of genetic and environmental effects, and improved measurement and classification of childhood disorders. """"""""Child-based"""""""" risk factors include earlier symptoms, temperament and stress reactivity, basal and reactive cortisol, testosterone and DHEA, cognitive abilities and attributional styles, and cognitive-affective processing skills. Family and other psychosocial risk factors include parental diagnosis and family history of psychopathology, twin-twin and twin-parent social interaction styles, multiple facets of family stress, and negative parenting. The research methods that we employ include structured diagnostic interviews with caregivers and children, medical records, observer ratings, child self-report and parent-report questionnaires, videotaped home-based behavioral batteries, and computer-based testing (mostly reaction time tasks). The study's significance lies in understanding how known risk factors interact and/or mediate each other's effects on child psychopathology in a genetically informative, longitudinal design. Twin methodology allows us to parse phenotypic variance and covariance among measures into genetic and environmental components, and the components are studied developmentally. The results should also enhance our understanding of comorbidity, heterogeneity within disorders, and the association of disorders with traits. The project's public health relevance lies in its identification of risk factors for common childhood disorders and its investigation of how they interact in the context of genetic and environmental factors. The knowledge gained should inform efforts toward early detection, improved interventions, and better classification of childhood disorders.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Research Project (R01)
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Behavioral Genetics and Epidemiology Study Section (BGES)
Program Officer
Zehr, Julia L
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University of Wisconsin Madison
Other Domestic Higher Education
United States
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Burghy, Cory A; Fox, Michelle E; Cornejo, M Daniela et al. (2016) Experience-Driven Differences in Childhood Cortisol Predict Affect-Relevant Brain Function and Coping in Adolescent Monozygotic Twins. Sci Rep 6:37081
Van Hulle, Carol A; Clifford, Sierra; Moore, Mollie N et al. (2016) Partial replication of two rumination-related candidate gene studies. Cogn Emot :1-9
Scott, Brandon G; Lemery-Chalfant, Kathryn; Clifford, Sierra et al. (2016) A Twin Factor Mixture Modeling Approach to Childhood Temperament: Differential Heritability. Child Dev :
Clifford, Sierra; Lemery-Chalfant, Kathryn; Goldsmith, H Hill (2015) The Unique and Shared Genetic and Environmental Contributions to Fear, Anger, and Sadness in Childhood. Child Dev 86:1538-56
Van Hulle, Carol A; Moore, Mollie N; Shirtcliff, Elizabeth A et al. (2015) Genetic and Environmental Contributions to Covariation Between DHEA and Testosterone in Adolescent Twins. Behav Genet 45:324-40
Lundwall, Rebecca A; Dannemiller, James L; Goldsmith, H Hill (2015) Genetic associations with reflexive visual attention in infancy and childhood. Dev Sci :
Van Hulle, Carol; Lemery-Chalfant, Kathryn; Goldsmith, H Hill (2015) Trajectories of Sensory Over-Responsivity from Early to Middle Childhood: Birth and Temperament Risk Factors. PLoS One 10:e0129968
Eggum-Wilkens, Natalie D; Lemery-Chalfant, Kathryn; Aksan, Nazan et al. (2015) Self-Conscious Shyness: Growth during Toddlerhood, Strong Role of Genetics, and No Prediction from Fearful Shyness. Infancy 20:160-188
Vendlinski, Matthew K; Javaras, Kristin N; Van Hulle, Carol A et al. (2014) Relative influence of genetics and shared environment on child mental health symptoms depends on comorbidity. PLoS One 9:e103080
Brooker, Rebecca J; Buss, Kristin A; Lemery-Chalfant, Kathryn et al. (2013) The development of stranger fear in infancy and toddlerhood: normative development, individual differences, antecedents, and outcomes. Dev Sci 16:864-78

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