Using the resources of an epidemiologically defined, longitudinal twin study, we examine developmental course and biopsychosocial risks for childhood psychopathology. Building on existing screening at ages 2 and 7 years, we characterize risk factors at ages 2, 7, and 12 relevant to the development of internalizing (anxiety and depression), externalizing (oppositional and conduct disorder), and ADHD. Most of our at-risk cases qualify for a DSM-IV diagnosis, yet we include individuals with sub-threshold symptoms and a large control group.
Specific aims i nclude characterization of risk factors, analysis of genetic and environmental effects, and improved measurement and classification of childhood disorders. """"""""Child-based"""""""" risk factors include earlier symptoms, temperament and stress reactivity, basal and reactive cortisol, testosterone and DHEA, cognitive abilities and attributional styles, and cognitive-affective processing skills. Family and other psychosocial risk factors include parental diagnosis and family history of psychopathology, twin-twin and twin-parent social interaction styles, multiple facets of family stress, and negative parenting. The research methods that we employ include structured diagnostic interviews with caregivers and children, medical records, observer ratings, child self-report and parent-report questionnaires, videotaped home-based behavioral batteries, and computer-based testing (mostly reaction time tasks). The study's significance lies in understanding how known risk factors interact and/or mediate each other's effects on child psychopathology in a genetically informative, longitudinal design. Twin methodology allows us to parse phenotypic variance and covariance among measures into genetic and environmental components, and the components are studied developmentally. The results should also enhance our understanding of comorbidity, heterogeneity within disorders, and the association of disorders with traits. The project's public health relevance lies in its identification of risk factors for common childhood disorders and its investigation of how they interact in the context of genetic and environmental factors. The knowledge gained should inform efforts toward early detection, improved interventions, and better classification of childhood disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH059785-09
Application #
7727367
Study Section
Behavioral Genetics and Epidemiology Study Section (BGES)
Program Officer
Zehr, Julia L
Project Start
1999-12-10
Project End
2011-11-30
Budget Start
2009-12-01
Budget End
2010-11-30
Support Year
9
Fiscal Year
2010
Total Cost
$515,203
Indirect Cost
Name
University of Wisconsin Madison
Department
Pediatrics
Type
Other Domestic Higher Education
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Adluru, Nagesh; Luo, Zhan; Van Hulle, Carol A et al. (2017) Anxiety-related experience-dependent white matter structural differences in adolescence: A monozygotic twin difference approach. Sci Rep 7:8749
Gagne, Jeffrey R; O'Sullivan, Deirdre L; Schmidt, Nicole L et al. (2017) The Shared Etiology of Attentional Control and Anxiety: An Adolescent Twin Study. J Res Adolesc 27:122-138
Van Hulle, Carol A; Moore, Mollie N; Lemery-Chalfant, Kathryn et al. (2017) Infant stranger fear trajectories predict anxious behaviors and diurnal cortisol rhythm during childhood. Dev Psychopathol 29:1119-1130
Lundwall, Rebecca A; Dannemiller, James L; Goldsmith, H Hill (2017) Genetic associations with reflexive visual attention in infancy and childhood. Dev Sci 20:
Van Hulle, Carol A; Lemery-Chalfant, Kathryn; Hill Goldsmith, H (2017) Parent-Offspring Transmission of Internalizing and Sensory over-Responsivity Symptoms in Adolescence. J Abnorm Child Psychol :
Brooker, Rebecca J; Canen, Mara J; Davidson, Richard J et al. (2017) Short- and long-term stability of alpha asymmetry in infants: Baseline and affective measures. Psychophysiology 54:1100-1109
Sarkisian, Katherine; Van Hulle, Carol; Lemery-Chalfant, Kathryn et al. (2017) Childhood inhibitory control and adolescent impulsivity and novelty seeking as differential predictors of relational and overt aggression. J Res Pers 67:144-150
Scott, Brandon G; Lemery-Chalfant, Kathryn; Clifford, Sierra et al. (2016) A Twin Factor Mixture Modeling Approach to Childhood Temperament: Differential Heritability. Child Dev 87:1940-1955
Brooker, Rebecca J; Davidson, Richard J; Goldsmith, H Hill (2016) Maternal negative affect during infancy is linked to disrupted patterns of diurnal cortisol and alpha asymmetry across contexts during childhood. J Exp Child Psychol 142:274-90
Burghy, Cory A; Fox, Michelle E; Cornejo, M Daniela et al. (2016) Experience-Driven Differences in Childhood Cortisol Predict Affect-Relevant Brain Function and Coping in Adolescent Monozygotic Twins. Sci Rep 6:37081

Showing the most recent 10 out of 39 publications