This application is based on the hypothesis that at least partially distinct neural and cognitive mechanisms are involved in the etiology of and recovery from Attention-deficit/Hyperactivity Disorder - combined type (ADHD-C). We posit that ADHD-C is due to a primary deficit in a neural system emerging from the reticular formation within the hindbrain/midbrain region that is present early in ontogeny and remains relatively static throughout the lifetime. Further, we posit that the diminution of symptoms frequently seen throughout development is related to the degree to which frontostriatal systems are able to compensate for these early deficits through the use of effort or """"""""top-down"""""""" executive control. To test this hypothesis, we propose to use functional magnetic resonance imaging (fMRI) along with neurocognitive measures in three groups of young adults. Two groups consist of patients from a longitudinal sample, all of whom met criteria for ADHD-C during childhood. Among these, many can be clearly identified either as ADHD persisters (ADHD-P) or ADHD remitters (ADHD-R). In addition, we have well-matched controls who never met criteria for any subtype of ADHD. Thus, we will evaluate the neural correlates of diverse developmental pathways in ADHD-C. If our hypotheses are correct, behavioral and fMRI indices of the system emerging the reticular formation should differ from controls in those who had childhood ADHD-C irrespective of adult clinical status. In contrast, measures of frontostriatal function should vary as a function of adult status such that more severe ADHD symptoms in adulthood are associated with poorer efficiency on these measures while those no longer having significant ADHD symptoms should perform more similarly to never-ADHD controls.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Research Project (R01)
Project #
Application #
Study Section
Child Psychopathology and Developmental Disabilities Study Section (CPDD)
Program Officer
Friedman-Hill, Stacia
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Queens College
Schools of Arts and Sciences
United States
Zip Code
Miller, M L; Ren, Y; Szutorisz, H et al. (2017) Ventral striatal regulation of CREM mediates impulsive action and drug addiction vulnerability. Mol Psychiatry :
Schulz, Kurt P; Li, Xiaobo; Clerkin, Suzanne M et al. (2017) Prefrontal and parietal correlates of cognitive control related to the adult outcome of attention-deficit/hyperactivity disorder diagnosed in childhood. Cortex 90:1-11
De Sanctis, Virginia A; Newcorn, Jeffrey H; Halperin, Jeffrey M (2014) A prospective look at substance use and criminal behavior in urban ADHD youth: what is the role of maltreatment history on outcome? Atten Defic Hyperact Disord 6:79-86
Schulz, Kurt P; B├ędard, Anne-Claude V; Fan, Jin et al. (2014) Emotional bias of cognitive control in adults with childhood attention-deficit/hyperactivity disorder. Neuroimage Clin 5:1-9
Trampush, Joey W; Jacobs, Michelle M; Hurd, Yasmin L et al. (2014) Moderator effects of working memory on the stability of ADHD symptoms by dopamine receptor gene polymorphisms during development. Dev Sci 17:584-95
Harty, Seth C; Galanopoulos, Stavroula; Newcorn, Jeffrey H et al. (2013) Delinquency, aggression, and attention-related problem behaviors differentially predict adolescent substance use in individuals diagnosed with ADHD. Am J Addict 22:543-50
Clerkin, Suzanne M; Schulz, Kurt P; Berwid, Olga G et al. (2013) Thalamo-cortical activation and connectivity during response preparation in adults with persistent and remitted ADHD. Am J Psychiatry 170:1011-9
De Sanctis, Virginia A; Nomura, Yoko; Newcorn, Jeffrey H et al. (2012) Childhood maltreatment and conduct disorder: independent predictors of criminal outcomes in ADHD youth. Child Abuse Negl 36:782-9
Halperin, Jeffrey M; Rucklidge, Julia J; Powers, Robyn L et al. (2011) Childhood CBCL bipolar profile and adolescent/young adult personality disorders: a 9-year follow-up. J Affect Disord 130:155-61
Harty, Seth C; Ivanov, Iliyan; Newcorn, Jeffrey H et al. (2011) The impact of conduct disorder and stimulant medication on later substance use in an ethnically diverse sample of individuals with attention-deficit/hyperactivity disorder in childhood. J Child Adolesc Psychopharmacol 21:331-9

Showing the most recent 10 out of 22 publications