Disruption of positive affect is a problem in anhedonia, dysphoria and other emotional Positive pathologies ranging from depression to addiction to schizophrenia. affective reaction is needed for well-being in normal daily life. To interpret why positive affect goes wrong in emotional disorders it is first necessary to understand how brain systems  normally generate positive affective reactions to pleasant events ('liking'). Yet little is known about how brains generate normal 'liking'reactions to rewards. This project will study brain 'hedonic hotspots'(cubic-millimeter sites able to magnify 'liking') that generate positive affective reactions to a prototypical reward, sweetness. The project will study opioid and endocannabinoid hedonic hotspots in the nucleus accumbens and ventral pallidum that underlie hedonic 'liking'reactions and motivational 'wanting'for natural food reward. The project will combine microinjection techniques with procedures for mapping localization of function and measures of natural homologous 'liking'reactions shared by humans and rodents (taste reactivity paradigm). Predictions are that mu opioid and CB1 endocannabinoid mechanisms share same cubic-millimeter hedonic hotspots in medial shell of nucleus accumbens and in ventral pallidum, and that different accumbens-pallidum circuits can mediate 'liking'versus 'wanting'for the same reward. Results should reveal important features of mechanisms within limbic hotspots that enhance hedonic reactions above normal. It will also reveal the normal roles of those same brain mechanisms in generating ordinary levels of positive affect, and in appetite states such as hunger that modulate hedonic impact. Altogether, the results will provide valuable information about the neural systems that generate positive affect for natural reward. Improved understanding of how brains generate positive affect should provide useful insights and eventual improvements in treatment for the disruption of positive affect involved in eating disorders, addiction, depression, schizophrenia and other mood disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH063649-10
Application #
8265817
Study Section
Neurobiology of Motivated Behavior Study Section (NMB)
Program Officer
Rossi, Andrew
Project Start
2001-05-01
Project End
2013-07-31
Budget Start
2012-03-01
Budget End
2013-07-31
Support Year
10
Fiscal Year
2012
Total Cost
$330,533
Indirect Cost
$107,783
Name
University of Michigan Ann Arbor
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
DiFeliceantonio, Alexandra G; Berridge, Kent C (2016) Dorsolateral neostriatum contribution to incentive salience: opioid or dopamine stimulation makes one reward cue more motivationally attractive than another. Eur J Neurosci 43:1203-18
Itoga, Christy A; Berridge, Kent C; Aldridge, J Wayne (2016) Ventral pallidal coding of a learned taste aversion. Behav Brain Res 300:175-83
Kalueff, Allan V; Stewart, Adam Michael; Song, Cai et al. (2016) Neurobiology of rodent self-grooming and its value for translational neuroscience. Nat Rev Neurosci 17:45-59
Berridge, Kent C; Robinson, Terry E (2016) Liking, wanting, and the incentive-sensitization theory of addiction. Am Psychol 71:670-679
Castro, Daniel C; Terry, Rachel A; Berridge, Kent C (2016) Orexin in Rostral Hotspot of Nucleus Accumbens Enhances Sucrose 'Liking' and Intake but Scopolamine in Caudal Shell Shifts 'Liking' Toward 'Disgust' and 'Fear'. Neuropsychopharmacology 41:2101-11
Robinson, Mike J F; Anselme, Patrick; Suchomel, Kristen et al. (2015) Amphetamine-induced sensitization and reward uncertainty similarly enhance incentive salience for conditioned cues. Behav Neurosci 129:502-11
Berridge, Kent C; Kringelbach, Morten L (2015) Pleasure systems in the brain. Neuron 86:646-64
Castro, Daniel C; Cole, Shannon L; Berridge, Kent C (2015) Lateral hypothalamus, nucleus accumbens, and ventral pallidum roles in eating and hunger: interactions between homeostatic and reward circuitry. Front Syst Neurosci 9:90
Robinson, Mike J F; Burghardt, Paul R; Patterson, Christa M et al. (2015) Individual Differences in Cue-Induced Motivation and Striatal Systems in Rats Susceptible to Diet-Induced Obesity. Neuropsychopharmacology 40:2113-23
Castro, D C; Berridge, K C (2014) Advances in the neurobiological bases for food 'liking' versus 'wanting'. Physiol Behav 136:22-30

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