This is a 5-year A1 competitive renewal to study the impact of sudden parental death on children. During the initial project period, we recruited a cohort of 245 children who have lost a parent to suicide, accident, or sudden natural death, and a demographically similar, non-bereaved control group of 185 children and assessed them at 1 and 2 years after parental death. We find evidence of a persistent impact two years after the death: parental bereavement quadruples the risk for child depression, even adjusting for pre-death risk factors. We propose to reassess this cohort at 3 and 6 years after the parental death for a total of 4 follow-up assessment points in order to examine the relationship between parental loss and child outcomes in the domains of psychopathology (e.g., incident disorder, symptom trajectory), attainment of developmental competence (educational, vocational, relational), and health-related outcomes (e.g., BMI, impact on the hypothalamic pituitary adrenal [HPA] axis). We evaluate the construct and discriminant validity of complicated grief to determine if it has a stable factor structure and explains a unique proportion of the variance in outcome. We test an explanatory model by examining specific pathways that may mediate (e.g., child coping, family cohesion) or moderate (e.g., pre-death psychopathology, gender) the relationship between parental death and child mental health, developmental, and physical health outcomes. As an exploratory aim, we examine if polymorphisms in genes may moderate the relationship between parent death and cortisol response to a social stressor (e.g., glucocorticoid receptor) or depression (e.g., serotonin transporter promoter). This project will lead to new knowledge, because it: (1) is the only controlled, prospective study of parentally bereaved children with a follow-up period of longer than 2 years;(2) assesses outcomes complementary to psychiatric outcome, namely developmental competency, health, and the HPA axis;(3) tests models of mediation and moderation;(4) is large enough to assess if parental bereavement by suicide is uniquely deleterious;and (5) will address whether complicated grief in youth has construct and discriminant validity and has a direct impact on functional outcome. These results will help to identify bereaved youth and families at risk for sub-optimal mental and physical health and developmental outcomes, thus framing targets for future prevention and intervention studies.Project Narrative: The loss of a parent is widely recognized to be among the most stressful events that a child can experience, and numerous retrospective studies indicate that parent loss has serious and enduring mental health effects. However, there have been no long-term, controlled, prospective studies of the effects of parental bereavement on children.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH065368-09
Application #
8005015
Study Section
Psychosocial Development, Risk and Prevention Study Section (PDRP)
Program Officer
Garriock, Holly A
Project Start
2002-08-09
Project End
2012-12-31
Budget Start
2011-01-01
Budget End
2011-12-31
Support Year
9
Fiscal Year
2011
Total Cost
$519,909
Indirect Cost
Name
University of Pittsburgh
Department
Psychiatry
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Melhem, Nadine M; Brent, David (2016) Commentary: The course of depression after childhood parental death - a reflection on Berg et al. (2016). J Child Psychol Psychiatry 57:1467-1469
Kerestes, Rebecca; Segreti, Anna Maria; Pan, Lisa A et al. (2016) Altered neural function to happy faces in adolescents with and at risk for depression. J Affect Disord 192:143-52
Pan, Lisa A; Ramos, Lisa; Segreti, AnnaMaria et al. (2015) Right superior temporal gyrus volume in adolescents with a history of suicide attempt. Br J Psychiatry 206:339-40
Hamdan, Sami; Melhem, Nadine M; Porta, Giovanna et al. (2013) Alcohol and substance abuse in parentally bereaved youth. J Clin Psychiatry 74:828-33
Melhem, Nadine M; Porta, Giovanna; Walker Payne, Monica et al. (2013) Identifying prolonged grief reactions in children: dimensional and diagnostic approaches. J Am Acad Child Adolesc Psychiatry 52:599-607.e7
Weinberg, Rebecca J; Dietz, Laura J; Stoyak, Samuel et al. (2013) A prospective study of parentally bereaved youth, caregiver depression, and body mass index. J Clin Psychiatry 74:834-40
Pan, L A; Hassel, S; Segreti, A M et al. (2013) Differential patterns of activity and functional connectivity in emotion processing neural circuitry to angry and happy faces in adolescents with and without suicide attempt. Psychol Med 43:2129-42
Brent, David A; McMakin, Dana L; Kennard, Betsy D et al. (2013) Protecting adolescents from self-harm: a critical review of intervention studies. J Am Acad Child Adolesc Psychiatry 52:1260-71
Dietz, Laura J; Stoyak, Samuel; Melhem, Nadine et al. (2013) Cortisol response to social stress in parentally bereaved youth. Biol Psychiatry 73:379-87
Pan, Lisa; Segreti, Annamaria; Almeida, Jorge et al. (2013) Preserved hippocampal function during learning in the context of risk in adolescent suicide attempt. Psychiatry Res 211:112-8

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