Schizophrenia is an illness with major public health consequences that is characterized by disturbances in emotion and cognition that often severely impair life function. Despite the central role of emotional disturbances in the phenomenology of schizophrenia, relatively little empirical work has been devoted to the study of emotion or emotion-cognition interactions in this illness. The goal of this project is to begin to elucidate the psychological and neurobiological bases of disturbances in emotional processing and emotion cognition interactions in this debilitating disorder. Building upon our previous work on cognitive deficits in schizophrenia, this proposal will test the following hypotheses: 1) at least a subset of emotional disturbances in schizophrenia, as well as abnormal emotion-cognition interactions, reflect an inability to contextually modulate emotional processing; and 2) difficulties modulating emotional processing in schizophrenia reflect disturbances in the function of dorsolateral prefrontal cortex and hippocampus and their connectivity with other brain regions involved in emotional processing (i.e., amygdala, anterior cingulate, orbital-medial prefrontal cortex). To test these hypotheses we will use state-of-the-art functional neuroimaging, behavioral, and psychophysiological techniques to study a large cohort of individuals with schizophrenia and demographically matched controls.
The Specific Aims of this proposal will test hypotheses regarding: 1) conditions in which individuals with schizophrenia should demonstrate intact emotional processing (as indexed by self-report, autonomic responses and brain activity); 2) conditions in which individuals with schizophrenia should demonstrate reduced emotional processing; 3) conditions in which individuals with schizophrenia should demonstrate enhanced emotional processing and disturbed emotion-cognition interactions; and 4) which specific symptoms will and will not be associated with disturbed emotional processing in schizophrenia. The results of these studies have the potential to vastly advance our understanding of emotional processing in schizophrenia and its influence on cognition. Such deficits are core aspects of schizophrenia that lead to functional disability, and thus a better understanding of their nature and causes is central to our attempts to better prevent and treat this illness.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Research Project (R01)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1-BDCN-2 (02))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Washington University
Schools of Arts and Sciences
Saint Louis
United States
Zip Code
Eisenstein, Sarah A; Bogdan, Ryan; Chen, Ling et al. (2017) Preliminary evidence that negative symptom severity relates to multilocus genetic profile for dopamine signaling capacity and D2 receptor binding in healthy controls and in schizophrenia. J Psychiatr Res 86:9-17
Moran, Erin K; Culbreth, Adam J; Barch, Deanna M (2017) Ecological momentary assessment of negative symptoms in schizophrenia: Relationships to effort-based decision making and reinforcement learning. J Abnorm Psychol 126:96-105
Culbreth, Adam J; Westbrook, Andrew; Daw, Nathaniel D et al. (2016) Reduced model-based decision-making in schizophrenia. J Abnorm Psychol 125:777-787
Luby, Joan L; Belden, Andy C; Jackson, Joshua J et al. (2016) Early Childhood Depression and Alterations in the Trajectory of Gray Matter Maturation in Middle Childhood and Early Adolescence. JAMA Psychiatry 73:31-8
Culbreth, Adam; Westbrook, Andrew; Barch, Deanna (2016) Negative symptoms are associated with an increased subjective cost of cognitive effort. J Abnorm Psychol 125:528-536
Lerman-Sinkoff, Dov B; Barch, Deanna M (2016) Network community structure alterations in adult schizophrenia: identification and localization of alterations. Neuroimage Clin 10:96-106
Sheffield, Julia M; Barch, Deanna M (2016) Cognition and resting-state functional connectivity in schizophrenia. Neurosci Biobehav Rev 61:108-20
Eisenstein, Sarah A; Bogdan, Ryan; Love-Gregory, Latisha et al. (2016) Prediction of striatal D2 receptor binding by DRD2/ANKK1 TaqIA allele status. Synapse 70:418-31
Chung, Yu Sun; Barch, Deanna M (2016) Frontal-striatum dysfunction during reward processing: Relationships to amotivation in schizophrenia. J Abnorm Psychol 125:453-69
Dowd, Erin C; Frank, Michael J; Collins, Anne et al. (2016) Probabilistic Reinforcement Learning in Patients With Schizophrenia: Relationships to Anhedonia and Avolition. Biol Psychiatry Cogn Neurosci Neuroimaging 1:460-473

Showing the most recent 10 out of 55 publications