Vocal learning in songbirds is a unique, experimentally accessible model of human vocal learning that also exemplifies the general process of motor learning using sensory feedback. A male songbird learns his courtship song by first memorizing his father's song, and later using auditory feedback to match his own song to his memory of his father's song. One major advantage to this model system is the existence of separate forebrain circuits involved in producing the song and in learning it. The so-called """"""""anterior forebrain pathway"""""""", which is essential for vocal learning, has recently been found to bear gross similarities to the mammalian basal ganglia pathway, which is known to be involved in motor control and motor learning. Specifically, the general circuit connectivity, neurotransmitters used, and neuron classes present, are consistent with the hypothesis that the same basic circuitry underlies information processing in avian and mammalian basal ganglia. The experiments proposed here will use electrophysiological and morphological approaches to test whether key microcircuitry of the anterior forebrain pathway supports this view. In addition, the experiments will test whether neuromodulatory actions of dopamine in the anterior forebrain pathway are similar to those in mammals. These experiments will provide necessary information about how the avian anterior forebrain pathway works. If the hypotheses are supported, two major benefits will ensue. First, work on the avian song system will accelerate because it can be guided by the wealth of information already available for mammals. Moreover, the song system, with its advantages of a well-studied, naturally-learned behavior, will be validated as a more directly applicable model system of mammalian basal ganglia function than heretofore realized. Such complementary approaches to understanding the basal ganglia are valuable because approaches to disorders of the basal ganglia such as Parkinson's and Huntington's diseases will likely require fundamental understanding of information processing in the basal ganglia. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH066128-04
Application #
7036542
Study Section
Integrative, Functional and Cognitive Neuroscience 8 (IFCN)
Program Officer
Vicentic, Aleksandra
Project Start
2003-03-01
Project End
2008-02-29
Budget Start
2006-03-01
Budget End
2007-02-28
Support Year
4
Fiscal Year
2006
Total Cost
$217,088
Indirect Cost
Name
University of Washington
Department
Zoology
Type
Schools of Arts and Sciences
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
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Ding, Long; Perkel, David J (2014) Two tales of how expectation of reward modulates behavior. Curr Opin Neurobiol 29:142-7
Wood, William E; Roseberry, Thomas K; Perkel, David J (2013) HTR2 receptors in a songbird premotor cortical-like area modulate spectral characteristics of zebra finch song. J Neurosci 33:2908-15
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Leblois, Arthur; Perkel, David J (2012) Striatal dopamine modulates song spectral but not temporal features through D1 receptors. Eur J Neurosci 35:1771-81
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Sizemore, Max; Perkel, David J (2011) Premotor synaptic plasticity limited to the critical period for song learning. Proc Natl Acad Sci U S A 108:17492-7
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Wood, William E; Lovell, Peter V; Mello, Claudio V et al. (2011) Serotonin, via HTR2 receptors, excites neurons in a cortical-like premotor nucleus necessary for song learning and production. J Neurosci 31:13808-15

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