The ability to learn and remember is a critical survival skill whether you are a human or a fly. This proposal will exploit the behavioral and genetic richness of Drosophila to define and understand neuronal circuits that link sleep and memory. Humans spend roughly one third of their lives asleep. Amazingly, there is no consensus on why we and other animals sleep, only agreement that without sleep our brains do not function optimally. One recurring finding, with convincing data from humans, mammalian model systems, and Drosophila is that sleep is required for effective memory formation. We will investigate the role of the circadian clock in both sleep (Specific Aim #1) and memory formation (Specific Aim #2) using cell specific manipulations that alter neuronal excitability. We will identify and characterize the activity of cells that are downstream of the clock that generate sleep (Specific Aim #3).

Public Health Relevance

Lack of sleep is an increasingly serious human health problem in western society. Studies of the the linkage between sleep and memory in Drosophila will provide insight into how sleep affects learning in humans.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
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Neurobiology of Learning and Memory Study Section (LAM)
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Asanuma, Chiiko
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Brandeis University
Schools of Arts and Sciences
United States
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Vogels, Tim P; Griffith, Leslie C (2017) Editorial overview: Neurobiology of learning and plasticity 2017. Curr Opin Neurobiol 43:A1-A5
Kim, Eugene Z; Vienne, Julie; Rosbash, Michael et al. (2017) Nonreciprocal homeostatic compensation in Drosophila potassium channel mutants. J Neurophysiol 117:2125-2136
Guo, Fang; Yu, Junwei; Jung, Hyung Jae et al. (2016) Circadian neuron feedback controls the Drosophila sleep--activity profile. Nature 536:292-7
Parisky, Katherine M; Agosto Rivera, José L; Donelson, Nathan C et al. (2016) Reorganization of Sleep by Temperature in Drosophila Requires Light, the Homeostat, and the Circadian Clock. Curr Biol 26:882-92
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Haynes, Paula R; Christmann, Bethany L; Griffith, Leslie C (2015) A single pair of neurons links sleep to memory consolidation in Drosophila melanogaster. Elife 4:
Langenhan, Tobias; Barr, Maureen M; Bruchas, Michael R et al. (2015) Model Organisms in G Protein-Coupled Receptor Research. Mol Pharmacol 88:596-603
Griffith, Leslie C (2014) A big picture of a small brain. Elife 3:e05580
Griffith, Leslie C (2014) Up all night on a redeye flight. Elife 3:e02087
Chi, Michael W; Griffith, Leslie C; Vecsey, Christopher G (2014) Larval Population Density Alters Adult Sleep in Wild-Type Drosophila melanogaster but Not in Amnesiac Mutant Flies. Brain Sci 4:453-70

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