Adolescence is associated with the emergence of several sex-biased mental illnesses, including eating, mood, and conduct disorders and schizophrenia. Each of these psychopathologies involves impairments in social information processing and social proficiency, which together comprise the ability to recognize, perceive, and interpret socially-relevant information and to apply it appropriately in specific social contexts. A fundamental but unanswered question about normal adolescent development is which of these two aspects of adolescent maturation are governed by pubertal gonadal hormones and which are not, and what neural mechanisms underlie hormone-dependent and -independent remodeling of social behavior circuits. The proposed research uses a well-suited laboratory rodent model, the male Syrian hamster, to empirically test the hypothesis that the adolescent transition in social information processing is gonadal hormone-independent, while adolescent maturation of social proficiency is gonadal hormone-dependent. Using a conditioned place preference paradigm and experimental manipulation of social experience, Aim 1 will test the hypothesis that adolescent changes in social information processing are governed by hormone-independent developmental processes that alter the rewarding properties of social stimuli, whereas adolescent maturation of social proficiency, the ability to make behavioral adaptations in response to social experience, is programmed by testicular hormones during puberty.
Aim 2 will characterize neural activation patterns in response to female sensory stimuli, as indexed by fos expression, to determine how neural responses to social stimuli are altered by the presence or absence of testicular hormones during adolescent development. Using the cell birth-date marker bromo-deoxy-uridine in combination with markers of cell function and pharmacological inhibition of brain cytogenesis, Aim 3 will investigate whether the pubertal addition of new cells to social behavior circuits is a mechanism by which gonadal hormones organize the adolescent brain. This research will establish an understanding of hormone-dependent and hormone-independent components of the adolescent maturation of social behaviors, and will investigate a novel mechanism by which gonadal hormones organize and remodel the adolescent brain. The identification of specific aspects of normal adolescent development that are hormone-dependent versus hormone-independent will advance understanding of the role that pubertal hormones play in the etiology of sex-biased mental illnesses associated with adolescence, and will facilitate the development of more effective strategies for prevention and treatment of these disorders.

Public Health Relevance

This research project will investigate how gonadal hormones shape the structure and function of adolescent brain to influence the maturation of social behavior. The work will contribute to an understanding of the role of pubertal hormones in the etiology of sex-biased mental illnesses that involve impairments in social cognition, such as eating and mood disorders and schizophrenia.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
2R01MH068764-06A2
Application #
8131476
Study Section
Special Emphasis Panel (ZRG1-IFCN-H (03))
Program Officer
Simmons, Janine M
Project Start
2003-07-01
Project End
2013-08-31
Budget Start
2011-09-20
Budget End
2012-06-30
Support Year
6
Fiscal Year
2011
Total Cost
$373,126
Indirect Cost
Name
Michigan State University
Department
Neurosciences
Type
Schools of Arts and Sciences
DUNS #
193247145
City
East Lansing
State
MI
Country
United States
Zip Code
48824
Walker, Deena M; Bell, Margaret R; Flores, Cecilia et al. (2017) Adolescence and Reward: Making Sense of Neural and Behavioral Changes Amid the Chaos. J Neurosci 37:10855-10866
Molenda-Figueira, Heather A; Bell, Margaret R; De Lorme, Kayla C et al. (2017) Pubertal pair-housing facilitates adult sexual behavior in male rats. Dev Psychobiol 59:111-117
Schulz, Kalynn M; Sisk, Cheryl L (2016) The organizing actions of adolescent gonadal steroid hormones on brain and behavioral development. Neurosci Biobehav Rev 70:148-158
Sisk, Cheryl L (2016) Hormone-dependent adolescent organization of socio-sexual behaviors in mammals. Curr Opin Neurobiol 38:63-8
Bell, Margaret R; De Lorme, Kayla C; Figueira, Rayson J et al. (2013) Adolescent gain in positive valence of a socially relevant stimulus: engagement of the mesocorticolimbic reward circuitry. Eur J Neurosci 37:457-68
De Lorme, Kayla C; Sisk, Cheryl L (2013) Pubertal testosterone programs context-appropriate agonistic behavior and associated neural activation patterns in male Syrian hamsters. Physiol Behav 112-113:1-7
Mohr, Margaret A; Sisk, Cheryl L (2013) Pubertally born neurons and glia are functionally integrated into limbic and hypothalamic circuits of the male Syrian hamster. Proc Natl Acad Sci U S A 110:4792-7
De Lorme, Kayla; Bell, Margaret R; Sisk, Cheryl L (2013) The Teenage Brain: Social Reorientation and the Adolescent Brain-The Role of Gonadal Hormones in the Male Syrian Hamster. Curr Dir Psychol Sci 22:128-133
Bell, Margaret R; Meerts, Sarah H; Sisk, Cheryl L (2013) Adolescent brain maturation is necessary for adult-typical mesocorticolimbic responses to a rewarding social cue. Dev Neurobiol 73:856-69
Bell, Margaret R; Sisk, Cheryl L (2013) Dopamine mediates testosterone-induced social reward in male Syrian hamsters. Endocrinology 154:1225-34

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