The long-term goal of this project is to identify early temperamental/emotional precursors of major depressive disorder (MDD) and to trace the pathways from early temperamental emotionality to the development of MDD in order to provide a basis for the early identification of children at risk and for understanding how and when to intervene to prevent the onset or escalation of the disorder. This is a continuation of a longitudinal study of a large community sample of children (N = 559) who completed intensive assessments at ages 3 and 6, and whom we seek to re-evaluate at age 9. The goal of the current proposal is to map the pathways from early low positive emotionality (PE) and high negative emotionality (NE) to a set of intermediate outcomes in middle childhood that may serve as more proximal risk factors that set the stage for, and mediate, the surge in depressive disorders expected in adolescence and young adulthood. We hypothesize that low PE and high NE in early childhood will predict abnormalities in three important domains in middle childhood that may constitute intermediate outcomes on pathways to the development of MDD: (1) abnormalities in the processing of emotional information, assessed using behavioral and electrocortical laboratory paradigms;(2) one form of limbic hypothalamic-pituitary-adrenal axis dysregulation - elevated morning cortisol levels;and (3) subclinical depressive symptoms and anxiety symptoms/disorders. In addition, we will explore whether these intermediate outcomes differ as a function of sex and are associated with individual differences in the early phase of pubertal maturation (adrenarche). Finally, we will test the hypothesis that associations of early genetic and familial risk factors with emotional processing biases, elevated morning cortisol, and depressive and anxiety symptoms in middle childhood are mediated by early temperamental emotionality.

Public Health Relevance

The depressive disorders are highly prevalent and associated with significant mortality, morbidity, and economic costs. This project seeks to identify early behavioral precursors/risk factors for depression and understand the neurobiological and psychosocial processes through which these early manifestations develop into clinically significant disorders. This will contribute to understanding when and how to intervene in order to prevent the disorder and/or its progression.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH069942-09
Application #
8464268
Study Section
Child Psychopathology and Developmental Disabilities Study Section (CPDD)
Program Officer
Garriock, Holly A
Project Start
2003-12-01
Project End
2014-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
9
Fiscal Year
2013
Total Cost
$688,413
Indirect Cost
$246,012
Name
State University New York Stony Brook
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
804878247
City
Stony Brook
State
NY
Country
United States
Zip Code
11794
Goldstein, Brandon L; Hayden, Elizabeth P; Klein, Daniel N (2015) Stability of self-referent encoding task performance and associations with change in depressive symptoms from early to middle childhood. Cogn Emot 29:1445-55
Kujawa, Autumn; Dougherty, Lea; Durbin, C Emily et al. (2014) Emotion recognition in preschool children: associations with maternal depression and early parenting. Dev Psychopathol 26:159-70
Wasson, L T; Shaffer, J; Alcántara, C et al. (2014) The association of posttraumatic stress disorder and quality of life during the first year after acute coronary syndrome. Int J Cardiol 176:1042-3
Kujawa, Autumn; Arfer, Kodi B; Klein, Daniel N et al. (2014) Electrocortical reactivity to social feedback in youth: a pilot study of the Island Getaway task. Dev Cogn Neurosci 10:140-7
Kujawa, Autumn; Proudfit, Greg Hajcak; Klein, Daniel N (2014) Neural reactivity to rewards and losses in offspring of mothers and fathers with histories of depressive and anxiety disorders. J Abnorm Psychol 123:287-97
Bufferd, Sara J; Dougherty, Lea R; Olino, Thomas M et al. (2014) Predictors of the onset of depression in young children: a multi-method, multi-informant longitudinal study from ages 3 to 6. J Child Psychol Psychiatry 55:1279-87
Goldstein, Brandon L; Klein, Daniel N (2014) A review of selected candidate endophenotypes for depression. Clin Psychol Rev 34:417-27
Hayden, Elizabeth P; Hanna, Brigitte; Sheikh, Haroon I et al. (2013) Child dopamine active transporter 1 genotype and parenting: evidence for evocative gene-environment correlations. Dev Psychopathol 25:163-73
Torpey, Dana C; Hajcak, Greg; Kim, Jiyon et al. (2013) Error-related brain activity in young children: associations with parental anxiety and child temperamental negative emotionality. J Child Psychol Psychiatry 54:854-62
Dougherty, Lea R; Tolep, Marissa R; Bufferd, Sara J et al. (2013) Preschool anxiety disorders: comprehensive assessment of clinical, demographic, temperamental, familial, and life stress correlates. J Clin Child Adolesc Psychol 42:577-89

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