The overarching goal of the proposed research is to understand, from a cognitive neuroscience perspective, how information about an event is successfully retrieved from episodic memory. Functional magnetic resonance imaging (fMRI) and event-related potentials (ERPs) will be employed to identify neural activity elicited during the retrieval of experimental items such as words and pictures. One line of experiments will investigate the extent to which retrieval-related activity in the hippocampus selectively supports the recovery of qualitative information about the past. Other experiments will investigate the degree to which retrieval-related activity in different parts of the medial temporal lobe dissociates according to whether associations between items, or items and their contexts, are recollected. A third set of experiments will investigate the generality and functional significance of content-selective, retrieval-related cortical reinstatement effects. A final set of experiments will focus of the functional significance of retrieval-related activity in inferior posterior parietal cortex. These last experiments will take as their starting point the hypothesis that this region supports an 'episodic buffer'that serves as an interface between episodic and working memory, and facilitates conscious access to recollected information. Disabling impairments of episodic memory are prominent in several common neurological conditions, notably Alzheimer's disease and traumatic brain injury. Episodic memory dysfunction is also a significant component of several common psychiatric disorders, including schizophrenia, depression and post-traumatic stress disorder. In addition, episodic memory declines substantially and, relative to other kinds of memory, disproportionately, with increasing age. The proposed research will facilitate the detailed understanding of the neurocognitive processes that support normally-functioning episodic memory, an understanding that is necessary for the elucidation of different kinds of episodic memory disorders and the development of effective therapeutic interventions.

Public Health Relevance

Disabling impairments of episodic memory - memory for unique events - are found in numerous neurological and psychiatric conditions. The proposed research will contribute to the detailed understanding of normally-functioning episodic memory that is necessary if different kinds of episodic memory disorders are to be fully understood and effectively treated.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH072966-10
Application #
8500443
Study Section
Special Emphasis Panel (ZRG1-BBBP-D (06))
Program Officer
Osborn, Bettina D
Project Start
2004-12-01
Project End
2015-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
10
Fiscal Year
2013
Total Cost
$363,528
Indirect Cost
$125,928
Name
University of Texas-Dallas
Department
None
Type
Other Domestic Higher Education
DUNS #
800188161
City
Richardson
State
TX
Country
United States
Zip Code
75080
Elward, Rachael L; Vilberg, Kaia L; Rugg, Michael D (2015) Motivated Memories: Effects of Reward and Recollection in the Core Recollection Network and Beyond. Cereb Cortex 25:3159-66
Elward, Rachael L; Rugg, Michael D (2015) Retrieval Goal Modulates Memory for Context. J Cogn Neurosci 27:2529-40
Thakral, Preston P; Yu, Sarah S; Rugg, Michael D (2015) The hippocampus is sensitive to the mismatch in novelty between items and their contexts. Brain Res 1602:144-52
King, Danielle R; de Chastelaine, Marianne; Elward, Rachael L et al. (2015) Recollection-related increases in functional connectivity predict individual differences in memory accuracy. J Neurosci 35:1763-72
Thakral, Preston P; Wang, Tracy H; Rugg, Michael D (2015) Cortical reinstatement and the confidence and accuracy of source memory. Neuroimage 109:118-29
Vilberg, Kaia L; Rugg, Michael D (2014) Temporal dissociations within the core recollection network. Cogn Neurosci 5:77-84
Rugg, Michael D; Vilberg, Kaia L (2013) Brain networks underlying episodic memory retrieval. Curr Opin Neurobiol 23:255-60
Johnson, Jeffrey D; Suzuki, Maki; Rugg, Michael D (2013) Recollection, familiarity, and content-sensitivity in lateral parietal cortex: a high-resolution fMRI study. Front Hum Neurosci 7:219
Rugg, Michael D; Vilberg, Kaia L; Mattson, Julia T et al. (2012) Item memory, context memory and the hippocampus: fMRI evidence. Neuropsychologia 50:3070-9
Yu, Sarah S; Johnson, Jeffrey D; Rugg, Michael D (2012) Dissociation of Recollection-Related Neural Activity in Ventral Lateral Parietal Cortex. Cogn Neurosci 3:142-149

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