? Substantial numbers of depressed adolescents either decline antidepressant medication or quickly? discontinue such medications before benefits are expected. Recent controversies regarding the safety? of SSRI anti-depressants are likely to increase medication refusal. More than half of depressed? adolescents identified in primary care prefer psychosocial treatments, compared to.20% who prefer? medication. Among the psychotherapy alternatives to medication, CBT has the strongest research support.? We have already developed a collaborative care CBT model that we evaluated in a previous primary care? trial. However, this previous trial did not specifically examined its effects in the absence of medication? treatment. Therefore, we propose to conduct a two-arm, randomized, efficacy-effectiveness trial in a? Health Maintenance Organization (HMO), comparing a treatment as usual (TAD) control condition to TAU? plus brief, individual, collaborative care CBT. We will enroll 240 youth ages 12 to 18 who, during this? depressive episode, have either declined anti-depressant medication or who received a single dispense of? anti-depressant medication but quickly discontinued. All enrolled cases will be reassessed periodically? throughout a 24-month follow-up period. The primary clinical outcome is recovery from the index episode of? major depression, assessed via LIFE/K-SADS diagnosis. Secondary outcomes include continuous? depression symptomatology; depression response; rates of new, recurrent episodes of major depression in? the follow-up period; improvements in psychosocial function; clinical improvement; reduction in depressionrelated? dysfunction; parent/youth attitudes regarding treatment. We will also examine incremental costeffectiveness? of CBT compared to TAU from the HMO, family, and societal perspectives. We will conduct? exploratory analyses of mediation and moderation of depression treatment outcomes, and employ data from? the TAU control condition to estimate the usual outcomes for depressed youth who refuse/discontinue? antidepressant medication. Finally, we will examine how provider, parent and youth barriers, attitudes? and beliefs moderate outcomes, as well as possibly change over time as a function of participation? in this program.? The validation of a primary care model for brief CC-CBT may prove to be a significant benefit to? the sizeable numbers of depressed youth identified in primary care, and who elect not to try antidepressant? medication or quickly discontinue an initial trial.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH073918-02
Application #
7251426
Study Section
Services Research Review Committee (SRV)
Program Officer
Sherrill, Joel
Project Start
2006-07-01
Project End
2011-04-30
Budget Start
2007-05-01
Budget End
2008-04-30
Support Year
2
Fiscal Year
2007
Total Cost
$683,371
Indirect Cost
Name
Kaiser Foundation Research Institute
Department
Type
DUNS #
150829349
City
Oakland
State
CA
Country
United States
Zip Code
94612
Clarke, Gregory; DeBar, Lynn L; Pearson, John A et al. (2016) Cognitive Behavioral Therapy in Primary Care for Youth Declining Antidepressants: A Randomized Trial. Pediatrics 137: