The medial temporal lobes (MTL) are the critical substrate for episodic memory. It is undisputed that a division of labor exists within the MTL. However, there is very little consensus as to how to best characterize these distinctions. Although some convergent evidence exists for a division of labor, particularly concerning the distinction between perirhinal and hippocampal encoding processes, the nature of the distinction between perirhinal and parahippocampal cortex has been underspecified. Although there is strong convergence in the literature supporting a role for the hippocampus in relational processing, the role of the MTL cortex in item processing/familiarity is less well defined, and only partially supported by the literature. Importantly, investigation into the extent and form of domain specificity within MTL cortex will contribute substantially to our understanding of episodic memory function. A fundamental hallmark of normal and abnormal aging, as well as some psychopathologies, is the alteration in episodic memory. Through an understanding of the functional architecture of the episodic memory system, great insight can be gleaned into these memory related deficits that, for example, occur during disease progression as a consequence of Alzheimer's disease or have been seen in the pathophysiology of neuropsychiatric disorders such as depression and schizophrenia. Understanding the neural mechanisms underlying the formation of human memory is an important step in efforts to describe and treat conditions that impact memory and will, thus, have a great impact on public health issues regarding treatment of such conditions. The research proposed will use functional magnetic resonance imaging to elucidate the functions of the MTL considering informational domain as being critical to a complete model of MTL organization (Aims 1 and 2). In addition, whether relational encoding and retrieval, thought to be a hallmark of hippocampal function, extends to the binding of episodic events in time will be explored (AIM 3)

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH074692-04
Application #
7755360
Study Section
Neurobiology of Learning and Memory Study Section (LAM)
Program Officer
Osborn, Bettina D
Project Start
2007-01-01
Project End
2011-12-31
Budget Start
2010-01-01
Budget End
2010-12-31
Support Year
4
Fiscal Year
2010
Total Cost
$302,406
Indirect Cost
Name
New York University
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
041968306
City
New York
State
NY
Country
United States
Zip Code
10012
Clewett, David; Davachi, Lila (2017) The Ebb and Flow of Experience Determines the Temporal Structure of Memory. Curr Opin Behav Sci 17:186-193
Tompary, Alexa; Davachi, Lila (2017) Consolidation Promotes the Emergence of Representational Overlap in the Hippocampus and Medial Prefrontal Cortex. Neuron 96:228-241.e5
Murty, Vishnu P; Tompary, Alexa; Adcock, R Alison et al. (2017) Selectivity in Postencoding Connectivity with High-Level Visual Cortex Is Associated with Reward-Motivated Memory. J Neurosci 37:537-545
Patil, Anuya; Murty, Vishnu P; Dunsmoor, Joseph E et al. (2017) Reward retroactively enhances memory consolidation for related items. Learn Mem 24:65-69
Heusser, Andrew C; Poeppel, David; Ezzyat, Youssef et al. (2016) Episodic sequence memory is supported by a theta-gamma phase code. Nat Neurosci 19:1374-80
Murty, Vishnu P; FeldmanHall, Oriel; Hunter, Lindsay E et al. (2016) Episodic memories predict adaptive value-based decision-making. J Exp Psychol Gen 145:548-58
Tompary, Alexa; Duncan, Katherine; Davachi, Lila (2016) High-resolution investigation of memory-specific reinstatement in the hippocampus and perirhinal cortex. Hippocampus 26:995-1007
DuBrow, Sarah; Davachi, Lila (2016) Temporal binding within and across events. Neurobiol Learn Mem 134 Pt A:107-14
Yushkevich, Paul A; Amaral, Robert S C; Augustinack, Jean C et al. (2015) Quantitative comparison of 21 protocols for labeling hippocampal subfields and parahippocampal subregions in in vivo MRI: towards a harmonized segmentation protocol. Neuroimage 111:526-41
Denny, Bryan T; Inhoff, Marika C; Zerubavel, Noam et al. (2015) Getting Over It: Long-Lasting Effects of Emotion Regulation on Amygdala Response. Psychol Sci 26:1377-88

Showing the most recent 10 out of 39 publications