This R01 application proposes functional neuroimaging studies with human subjects to elucidate the role of the prefrontal cortex and amygdala in the processing of facial identities and expressions that predict different social outcomes. Presentations of facial expressions of emotion in neuroimaging studies have proven particularly robust stimuli for activating amygdala and prefrontal regions involved in processing biologically- relevant social cues. Further, these tasks have proven useful for revealing aberrant brain activation patterns in patients with various emotional disorders (e.g., anxiety, depression). Here we propose to further develop our facial expression tasks to increase our understanding of cortical-subcortical interactions during the processing of these socially relevant cues. The utility of this work is that it will provide for a better understanding of the basic rules that determine amygdala responses, and allow us to better understand how the amygdala interacts with reciprocally connected prefrontal areas when such expressions are encountered. The proposed studies comprise programmatic extensions of our previous work as well as incorporate a novel longitudinal study of the effect of regulatory experience on brain structure. This specific study builds off our recent exciting published finding showing that the structural integrity of an amygdala-prefrontal pathway predicts individual differences in reported anxiety. The experiments proposed here are critical for establishing an understanding of the normal pattern of adult human brain responsivity to these ubiquitous social cues. These data will be usefully compared to complementary developmental research (i.e., with children and adolescents) and will be amenable to direct translation to clinical populations.

Public Health Relevance

Facial expressions are everywhere. Indeed, we use the expressions of others on a moment-to-moment basis to predict what will happen next in our social world. The experiments proposed here will increase our understanding of the brain mechanisms involved in this learning. With this information, we can then better understand what goes wrong in the brains of individuals with major depression and anxiety disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH080716-06
Application #
8415846
Study Section
Social Psychology, Personality and Interpersonal Processes Study Section (SPIP)
Program Officer
Simmons, Janine M
Project Start
2007-02-01
Project End
2017-01-31
Budget Start
2013-02-01
Budget End
2014-01-31
Support Year
6
Fiscal Year
2013
Total Cost
$386,400
Indirect Cost
$146,400
Name
Dartmouth College
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
Davis, F Caroline; Neta, Maital; Kim, M Justin et al. (2016) Interpreting ambiguous social cues in unpredictable contexts. Soc Cogn Affect Neurosci 11:775-82
Mattek, Alison M; Whalen, Paul J; Berkowitz, Julia L et al. (2016) Differential effects of cognitive load on subjective versus motor responses to ambiguously valenced facial expressions. Emotion 16:929-36
Kim, M Justin; Solomon, Kimberly M; Neta, Maital et al. (2016) A face versus non-face context influences amygdala responses to masked fearful eye whites. Soc Cogn Affect Neurosci 11:1933-1941
Taylor, James M; Whalen, Paul J (2015) Neuroimaging and Anxiety: the Neural Substrates of Pathological and Non-pathological Anxiety. Curr Psychiatry Rep 17:49
Kim, M Justin; Neta, Maital; Davis, F Caroline et al. (2014) Botulinum toxin-induced facial muscle paralysis affects amygdala responses to the perception of emotional expressions: preliminary findings from an A-B-A design. Biol Mood Anxiety Disord 4:11
Taylor, James M; Whalen, Paul J (2014) Fearful, but not angry, expressions diffuse attention to peripheral targets in an attentional blink paradigm. Emotion 14:462-8
Neta, Maital; Kelley, William M; Whalen, Paul J (2013) Neural responses to ambiguity involve domain-general and domain-specific emotion processing systems. J Cogn Neurosci 25:547-57
Hopkins, M E; Davis, F C; Vantieghem, M R et al. (2012) Differential effects of acute and regular physical exercise on cognition and affect. Neuroscience 215:59-68
Kim, M Justin; Gee, Dylan G; Loucks, Rebecca A et al. (2011) Anxiety dissociates dorsal and ventral medial prefrontal cortex functional connectivity with the amygdala at rest. Cereb Cortex 21:1667-73
Wu, Yu-Chien; Field, Aaron S; Whalen, Paul J et al. (2011) Age- and gender-related changes in the normal human brain using hybrid diffusion imaging (HYDI). Neuroimage 54:1840-53

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