This R01 application proposes functional neuroimaging studies with human subjects to elucidate the role of the prefrontal cortex and amygdala in the processing of facial identities and expressions that predict different social outcomes. Presentations of facial expressions of emotion in neuroimaging studies have proven particularly robust stimuli for activating amygdala and prefrontal regions involved in processing biologically- relevant social cues. Further, these tasks have proven useful for revealing aberrant brain activation patterns in patients with various emotional disorders (e.g., anxiety, depression). Here we propose to further develop our facial expression tasks to increase our understanding of cortical-subcortical interactions during the processing of these socially relevant cues. The utility of this work is that it will provide for a better understanding of the basic rules that determine amygdala responses, and allow us to better understand how the amygdala interacts with reciprocally connected prefrontal areas when such expressions are encountered. The proposed studies comprise programmatic extensions of our previous work as well as incorporate a novel longitudinal study of the effect of regulatory experience on brain structure. This specific study builds off our recent exciting published finding showing that the structural integrity of an amygdala-prefrontal pathway predicts individual differences in reported anxiety. The experiments proposed here are critical for establishing an understanding of the normal pattern of adult human brain responsivity to these ubiquitous social cues. These data will be usefully compared to complementary developmental research (i.e., with children and adolescents) and will be amenable to direct translation to clinical populations.

Public Health Relevance

Facial expressions are everywhere. Indeed, we use the expressions of others on a moment-to-moment basis to predict what will happen next in our social world. The experiments proposed here will increase our understanding of the brain mechanisms involved in this learning. With this information, we can then better understand what goes wrong in the brains of individuals with major depression and anxiety disorders.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Research Project (R01)
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Social Psychology, Personality and Interpersonal Processes Study Section (SPIP)
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Simmons, Janine M
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Dartmouth College
Schools of Arts and Sciences
United States
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Taylor, James M; Whalen, Paul J (2014) Fearful, but not angry, expressions diffuse attention to peripheral targets in an attentional blink paradigm. Emotion 14:462-8
Davis, F Caroline; Somerville, Leah H; Ruberry, Erika J et al. (2011) A tale of two negatives: differential memory modulation by threat-related facial expressions. Emotion 11:647-55
Neta, Maital; Whalen, Paul J (2011) Individual differences in neural activity during a facial expression vs. identity working memory task. Neuroimage 56:1685-92
Kim, M Justin; Gee, Dylan G; Loucks, Rebecca A et al. (2011) Anxiety dissociates dorsal and ventral medial prefrontal cortex functional connectivity with the amygdala at rest. Cereb Cortex 21:1667-73
Wu, Yu-Chien; Field, Aaron S; Duncan, Ian D et al. (2011) High b-value and diffusion tensor imaging in a canine model of dysmyelination and brain maturation. Neuroimage 58:829-37
Kim, M Justin; Loucks, Rebecca A; Palmer, Amy L et al. (2011) The structural and functional connectivity of the amygdala: from normal emotion to pathological anxiety. Behav Brain Res 223:403-10
Wu, Yu-Chien; Field, Aaron S; Whalen, Paul J et al. (2011) Age- and gender-related changes in the normal human brain using hybrid diffusion imaging (HYDI). Neuroimage 54:1840-53
Somerville, Leah H; Whalen, Paul J; Kelley, William M (2010) Human bed nucleus of the stria terminalis indexes hypervigilant threat monitoring. Biol Psychiatry 68:416-24
Kim, M Justin; Loucks, Rebecca A; Neta, Maital et al. (2010) Behind the mask: the influence of mask-type on amygdala response to fearful faces. Soc Cogn Affect Neurosci 5:363-8
Davis, F Caroline; Johnstone, Tom; Mazzulla, Emily C et al. (2010) Regional response differences across the human amygdaloid complex during social conditioning. Cereb Cortex 20:612-21

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