We use our memories to guide our life. For the most part, we are able to effectively use memory to direct behavior as, and when, we want to. For example, although you know where your fridge is, you do not go there unless you are hungry. However, in certain disease-states, such as affective disorders and addiction, motivational control goes awry and behavior becomes compulsive. The long-term goal of this proposal is to understand how the brain systems encoding memory integrate with the neural networks that determine motivation. We will specifically investigate how the `motivation to feed'network interacts with appetitive memory (formation and retrieval) to guide food-seeking behavior at the appropriate time. We use the fruit fly Drosophila as our model system because it can learn, it has a relatively simple brain and it is amenable to a sophisticated genetic approach. We will use the most up to date technology available in Drosophila to manipulate and elucidate the role of monoaminergic and Neuropeptide Y signaling systems in the fly brain that have conserved counterparts in the mammalian brain. We therefore expect that these studies will have a major impact on strategies for human mnemonic therapy, addiction and a wide variety of mental disorders.

Public Health Relevance

The ability to appropriately direct behavior using our memories is something we take for granted. However, in certain disease-states, such as affective disorders and addiction, our motivational control goes awry and behavior runs amok. This proposal will explore how the brain systems encoding memory integrate with the neural networks that determine motivation. Our work will provide fundamental knowledge of how conserved cell signaling systems motivate behavioral memory performance and we expect these studies will provide relevant therapeutic avenues against a wide variety of mental disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH081982-05
Application #
8229897
Study Section
Neurobiology of Learning and Memory Study Section (LAM)
Program Officer
Asanuma, Chiiko
Project Start
2008-05-08
Project End
2013-06-28
Budget Start
2012-03-01
Budget End
2013-06-28
Support Year
5
Fiscal Year
2012
Total Cost
$103,508
Indirect Cost
$40,585
Name
University of Massachusetts Medical School Worcester
Department
Biology
Type
Schools of Medicine
DUNS #
603847393
City
Worcester
State
MA
Country
United States
Zip Code
01655
Perisse, Emmanuel; Burke, Christopher; Huetteroth, Wolf et al. (2013) Shocking revelations and saccharin sweetness in the study of Drosophila olfactory memory. Curr Biol 23:R752-63
Waddell, Scott (2013) Reinforcement signalling in Drosophila; dopamine does it all after all. Curr Opin Neurobiol 23:324-9
Perrat, Paola N; DasGupta, Shamik; Wang, Jie et al. (2013) Transposition-driven genomic heterogeneity in the Drosophila brain. Science 340:91-5
Perisse, Emmanuel; Yin, Yan; Lin, Andrew C et al. (2013) Different kenyon cell populations drive learned approach and avoidance in Drosophila. Neuron 79:945-56
Liu, Chang; Plaçais, Pierre-Yves; Yamagata, Nobuhiro et al. (2012) A subset of dopamine neurons signals reward for odour memory in Drosophila. Nature 488:512-6
Burke, Christopher J; Huetteroth, Wolf; Owald, David et al. (2012) Layered reward signalling through octopamine and dopamine in Drosophila. Nature 492:433-7
Huetteroth, Wolf; Waddell, Scott (2011) Bringing fly brains in line. Nat Methods 8:461-3
Huetteroth, Wolf; Waddell, Scott (2011) Hungry flies tune to vinegar. Cell 145:17-8
Krashes, Michael J; Waddell, Scott (2011) Drosophila appetitive olfactory conditioning. Cold Spring Harb Protoc 2011:pdb.prot5609
Perisse, Emmanuel; Waddell, Scott (2011) Associative memory: without a trace. Curr Biol 21:R579-81

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