This is a competitive renewal of a four-year study of cognitive markers of late-life suicide. Our overarching goal is to find factors predictive of high-lethality suicidal behavior in late life. Extending the stress-diathesis model, our research program seeks to understand how trait-like diatheses - impaired cognitive control, deficits in social processing, and impulsivity - are expressed in poor decisions, both in experimental paradigms and in the context of real-world decision making. Our current cross-sectional study focuses on cognitive correlates of late-life suicidal behavior, linking it to poor cognitive contro. Adding to a growing body of evidence, we have preliminary evidence that older suicide attempters are impaired in their decision-making. Further, we have important clues about dimensions of heterogeneity in suicidal behavior. We see that high-lethality suicide attempters struggle in complex environments and make poor social decisions. By contrast, we see a tendency toward short-sighted decisions falling under the broad category of impulsivity in people with low-lethality and unplanned suicide attempts. The proposed study examines the cognitive and neural underpinnings of disadvantageous decisions in individuals with high-lethality attempts. We propose to (i) relate cognitive control deficits to poor decision-making in complex, ambiguous environments in older suicide attempters, (ii) to describe neural system alterations that may underlie poor cognitive control and disadvantageous decisions, (iii) to extend our investigations to poor social decisions that may contribute to late-life suicidal behavior, and (iv to develop an algorithm for predicting suicide risk that incorporates these features in addition to established risk factors. These goals will be accomplished by two interlinked studies. Study I is a cross-sectional, case- control comparison of 70 high-lethality suicide attempters, 70 low-lethality suicide attempters, 70 non-suicidal depressed, and 50 non-psychiatric controls. We focus on older suicide attempters, as suicide rates are high in old age and because late-life suicide attempts, due to their serious and determined nature, offer a window into death by suicide. Study I will use a framework that combines behavioral economics and cognitive neuroscience, with multilevel clinical, behavioral, cognitive, and imaging assessments. Our sampling and assessment strategy was designed with particular attention to possible confounders. Study II will follow 250 older suicide attempters (110 enrolled to date + 140 newly recruited) for up to 4 years, capturing recurrent attempts. It will serve as a prospective validatin of our predictive model. The extensive clinical and behavioral/cognitive characterization combined with a machine learning approach will allow us to develop an algorithm for suicide risk prediction which can inform clinical practice. The investigative team includes experts in reward learning and model-based imaging (Dombrovski), geriatric neuroimaging (Aizeinstein), behavioral economics (De Bruine), analysis of neural and longitudinal data (Weissfield), decision neuroscience (Clark), neuropsychology of suicide (Keilp) and of geriatric depression (Butters).

Public Health Relevance

Every year, about 6000 people aged 65 and older die by suicide in the US, with non-fatal suicide attempts numbering at least 2-4 times as many;however, clinicians lack tools for identifying those at risk and targeted treatments. Suicide follows a decision process, and recent studies have shown that suicidal individuals are often bad at making decisions in other situations;this study specifically explores patterns of decision-making seen in older people with near-lethal suicide attempts.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
2R01MH085651-05
Application #
8630165
Study Section
Adult Psychopathology and Disorders of Aging Study Section (APDA)
Program Officer
Niederehe, George T
Project Start
2010-09-15
Project End
2019-05-31
Budget Start
2014-08-20
Budget End
2015-05-31
Support Year
5
Fiscal Year
2014
Total Cost
$496,314
Indirect Cost
$174,032
Name
University of Pittsburgh
Department
Psychiatry
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Gujral, Swathi; Ogbagaber, Semhar; Dombrovski, Alexandre Y et al. (2016) Course of cognitive impairment following attempted suicide in older adults. Int J Geriatr Psychiatry 31:592-600
Kasckow, John; Youk, Ada; Anderson, Stewart J et al. (2016) Trajectories of suicidal ideation in depressed older adults undergoing antidepressant treatment. J Psychiatr Res 73:96-101
Vanyukov, P M; Szanto, K; Hallquist, M N et al. (2016) Paralimbic and lateral prefrontal encoding of reward value during intertemporal choice in attempted suicide. Psychol Med 46:381-91
Kay, Daniel B; Dombrovski, Alexandre Y; Buysse, Daniel J et al. (2016) Insomnia is associated with suicide attempt in middle-aged and older adults with depression. Int Psychogeriatr 28:613-9
de Bruin, Wändi Bruine; Dombrovski, Alexandre Y; Parker, Andrew M et al. (2016) Late-life Depression, Suicidal Ideation, and Attempted Suicide: The Role of Individual Differences in Maximizing, Regret, and Negative Decision Outcomes. J Behav Decis Mak 29:363-371
Vanyukov, Polina M; Szanto, Katalin; Hallquist, Michael et al. (2016) Perceived burdensomeness is associated with low-lethality suicide attempts, dysfunctional interpersonal style, and younger rather than older age. Int J Geriatr Psychiatry :
Richard-Devantoy, Stéphane; Szanto, Katalin; Butters, Meryl A et al. (2015) Cognitive inhibition in older high-lethality suicide attempters. Int J Geriatr Psychiatry 30:274-83
Vanyukov, Polina M; Szanto, Katalin; Siegle, Greg J et al. (2015) Impulsive traits and unplanned suicide attempts predict exaggerated prefrontal response to angry faces in the elderly. Am J Geriatr Psychiatry 23:829-39
Dombrovski, A Y; Szanto, K; Clark, L et al. (2015) Corticostriatothalamic reward prediction error signals and executive control in late-life depression. Psychol Med 45:1413-24
Szanto, Katalin; Bruine de Bruin, Wändi; Parker, Andrew M et al. (2015) Decision-making competence and attempted suicide. J Clin Psychiatry 76:e1590-7

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