Sensitive periods are defined as a time in development during which the brain is particularly responsive to experiences in the form of patterns of activity (Daw, 1997).This time point may be termed a """"""""critical"""""""" period if the presence or absence of an experience results in irreversible change (Newport, Hindle, &Jackson, 2001;Trachtenberg &Stryker, 2001). Those factors that allow a circuit underlying development to be plastic - or render it unchangeable - are becoming increasingly well understood in a small number of domains (i.e., visual and perceptual development). However, there is a paucity of data on sensitive periods for normative social and emotional development in human infants and children and little is known about the effects of aberrant experiences during early development on the emergence of psychopathology. The case of infants abandoned since birth into institutions provides an opportunity to examine the effects of severe psychosocial deprivation and sensitive periods in typical neural, social-emotional and cognitive development, as well as in trajectories that lead to psychopathology. Over the past 10 years we have conducted just such a study in which infants, abandoned since birth and raised in institutions in Bucharest, Romania, were randomly assigned either to be removed from the institution and placed into a family/foster care intervention or to be left in the institutions to care as usual. These children have been followed through 8 years of age and thus far, the data through 54 months of age indicate that a) early institutionalization leads to perturbations in brain electrical activity, profound deficits and delays in cognitive and socio- emotional behaviors, and a greatly elevated incidence of psychiatric disorders and impairment, b) our intervention was broadly effective in enhancing children's development, but c) for specific domains of neural activity, language, cognition and social-emotional functioning there appear to be sensitive periods regulating recovery. In the current proposal, we will extend these analyses with the aim to predict mental health outcomes in two groups of children: those originally assigned to our Foster Care intervention [FCG] and those originally randomized to remain in the institution (Care as Usual Group [CAUG] when they are 12 years of age, and we will compare their functioning to typically developing age-matched Romanian children (Never Institutionalized Group [NIG]). Using both brain (EEG/ERP) and behavioral measures, we propose to 1) reexamine, at age 12, the long term impact of early institutionalization on mental health outcomes and the efficacy of our intervention in ameliorating the burden of mental health outcomes using an intent-to-treat design;2) examine how the dose of institutionalization (percent time spent in an institution) influences long term outcomes;and 3) examine sensitive periods in recovery from early institutionalization.
There are currently more than 70 million orphaned or abandoned children throughout the world. A common societal response to caring for such children is to house them in institutions. Children with histories of early institutionalization are at risk for developing a variety of mental health problems that have their origin in abnormal social behavior. The current application will examine the long term effects of early institutionalization on mental health outcomes in two groups of children with a history of institutionalization, as well as explore sensitive periods in recovery from institutionalization.
|Guyon-Harris, Katherine L; Humphreys, Kathryn L; Degnan, Kathryn et al. (2018) A prospective longitudinal study of reactive attachment disorder following early institutional care: considering variable- and person-centered approaches. Attach Hum Dev :1-16|
|Johnson, Dana E; Tang, Alva; Almas, Alisa N et al. (2018) Caregiving Disruptions Affect Growth and Pubertal Development in Early Adolescence in Institutionalized and Fostered Romanian Children: A Randomized Clinical Trial. J Pediatr 203:345-353.e3|
|Guyon-Harris, Katherine L; Humphreys, Kathryn L; Fox, Nathan A et al. (2018) Signs of attachment disorders and social functioning among early adolescents with a history of institutional care. Child Abuse Negl 88:96-106|
|Guyon-Harris, Katherine L; Humphreys, Kathryn L; Fox, Nathan A et al. (2018) Course of Disinhibited Social Engagement Disorder From Early Childhood to Early Adolescence. J Am Acad Child Adolesc Psychiatry 57:329-335.e2|
|Troller-Renfree, Sonya; Zeanah, Charles H; Nelson, Charles A et al. (2018) Neural and Cognitive Factors Influencing the Emergence of Psychopathology: Insights From the Bucharest Early Intervention Project. Child Dev Perspect 12:28-33|
|Sheridan, Margaret A; McLaughlin, Katie A; Winter, Warren et al. (2018) Early deprivation disruption of associative learning is a developmental pathway to depression and social problems. Nat Commun 9:2216|
|Lamm, Connie; Troller-Renfree, Sonya V; Zeanah, Charles H et al. (2018) Impact of early institutionalization on attention mechanisms underlying the inhibition of a planned action. Neuropsychologia 117:339-346|
|Tang, Alva; Slopen, Natalie; Nelson, Charles A et al. (2018) Catch-up growth, metabolic, and cardiovascular risk in post-institutionalized Romanian adolescents. Pediatr Res :|
|Humphreys, Kathryn L; Miron, Devi; McLaughlin, Katie A et al. (2018) Foster care promotes adaptive functioning in early adolescence among children who experienced severe, early deprivation. J Child Psychol Psychiatry 59:811-821|
|Bick, Johanna; Zeanah, Charles H; Fox, Nathan A et al. (2018) Memory and Executive Functioning in 12-Year-Old Children With a History of Institutional Rearing. Child Dev 89:495-508|
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