The current proposal aims to study neural mechanisms of social learning in healthy adults as a precursor to understanding the impact of mental illnesses on social functioning. Changes in social behavior are often the first symptoms of a striking array of neuropsychiatric disorders. However, whereas disruptions in memory, motor, or emotional functioning are readily recognized as symptoms of more serious underlying conditions, decision-making deficits are often overlooked, particularly in the social domain. Furthermore, there exist few behavioral measures or biomarkers to quantify such deficits, due in part to our limited knowledge of the underlying neural mechanisms and their relation to mental disorders. We do so via a tight integration of computational modeling of goal-directed social behavior, and testing the predictions generated using complementary experimental techniques with both fMRI and focal lesion patients. In particular, we focus on the role of dopamine and interactions between the basal ganglia and frontal cortices, which are together critical for goal-directed behavior and known to be affected in a variety of disorders. First, we will use the model, calibrated on observed behavior, to derive trial-by-trial regressors for use in functional neuroimaging experiments. Second, the estimated parameters of the model themselves can be used to compare across health and diseased groups, or find subtypes of the diseased groups. Finally, the neural correlates and the behavioral estimates can be combined in order to find novel brain-behavior markers of diseases. In this way, we seek to provide a unifying account of goal-directed behavior in both social and non- social settings, which has the potential to lead to development of new ways of classifying mental disorders based on dimensions of observable behavior and neurobiological measures.
The current proposal aims to study neural mechanisms of social learning in healthy adults as a precursor to understanding the impact of mental illnesses on social functioning. Changes in social behavior are often the first symptoms of a striking array of neuropsychiatric disorders. We seek to provide a unifying account of goal- directed behavior in both social and non-social settings using a neuroeconomic framework, which has the potential to lead to development of new ways of classifying mental disorders based on dimensions of observable behavior and neurobiological measures.
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|Zhong, Songfa; Chark, Robin; Hsu, Ming et al. (2016) Computational substrates of social norm enforcement by unaffected third parties. Neuroimage 129:95-104|
|SÃ¡ez, Ignacio; Zhu, Lusha; Set, Eric et al. (2015) Dopamine modulates egalitarian behavior in humans. Curr Biol 25:912-9|
|Hsu, Ming; Yoon, Carolyn (2015) The Neuroscience of Consumer Choice. Curr Opin Behav Sci 5:116-121|
|Hsu, Ming; Jenkins, Adrianna C (2015) Character studies. Nat Neurosci 18:1198-9|
|Chen, Yu-Ping; Nelson, Leif D; Hsu, Ming (2015) From "Where" to "What": Distributed Representations of Brand Associations in the Human Brain. J Mark Res 52:453-466|
|Zhu, Lusha; Jenkins, Adrianna C; Set, Eric et al. (2014) Damage to dorsolateral prefrontal cortex affects tradeoffs between honesty and self-interest. Nat Neurosci 17:1319-21|
|Bertoux, Maxime; Cova, Florian; Pessiglione, Mathias et al. (2014) Behavioral variant frontotemporal dementia patients do not succumb to the Allais paradox. Front Neurosci 8:287|
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