Borderline personality disorder (BPD) is a severe mental health condition that confers significant psychological and physical disability. Key features of the clinical presentation of borderline personality disorder include affect dysregulation, impulsivity and unstable relationships. While these features are classically borne out within social relationships, the neurobehavioral etiology of social decision-making in BPD has received limited investigation, despite the prominent role that interpersonal dysfunction plays in the expression of the disorder. To address this gap, the broad goal of this proposal is to detail the behavioral, computational and neural processes underlying three candidate abnormalities in social decision-making within BPD: (i) biases in risk appraisal when making decisions about social partners; (ii) hypersensitivity to prediction errors about social rewards and punishments; and, (iii) aggression-related social learning abnormalities. Thus, we combine well- characterized interactive games from decision neuroscience with functional magnetic resonance imaging to develop a sensitive and specific neuromechanistic understanding of the biological basis of interpersonal impairments in borderline PD. Specifically, we examine in BPD: (i) neural mechanisms underlying risk preferences in social and non-social decision-making (Aim 1); (ii) neural mechanisms of social reward/punishment sensitivity (Aim 2); and (iii) neural mechanisms contributing to impulsive interpersonal aggression (Aim 3).

Public Health Relevance

Borderline personality disorder (BPD) is a serious mental health condition that is characterized by emotional dysregulation, impulsivity, and unstable relationships. Interpersonal difficulties in BPD play a significant role in triggering suicidal thoughts and actions, and the human cost of this illness motivates our efforts to understand the biological causes of BPD. Specifically, we use functional neuroimaging while people interact with one another to identify neural mechanisms underlying social dysfunction in people suffering from BPD.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
1R01MH115221-01
Application #
9425864
Study Section
Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section (NPAS)
Program Officer
Morris, Sarah E
Project Start
2018-02-01
Project End
2022-12-31
Budget Start
2018-02-01
Budget End
2018-12-31
Support Year
1
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Virginia Polytechnic Institute and State University
Department
Type
Organized Research Units
DUNS #
003137015
City
Blacksburg
State
VA
Country
United States
Zip Code
24061