Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
3R01NS013559-12S1
Application #
3395245
Study Section
Neurology B Subcommittee 1 (NEUB)
Project Start
1987-09-01
Project End
1988-02-29
Budget Start
1987-09-01
Budget End
1988-02-29
Support Year
12
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Kennedy Krieger Research Institute, Inc.
Department
Type
DUNS #
City
Baltimore
State
MD
Country
United States
Zip Code
21205
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Ho, J K; Moser, H; Kishimoto, Y et al. (1995) Interactions of a very long chain fatty acid with model membranes and serum albumin. Implications for the pathogenesis of adrenoleukodystrophy. J Clin Invest 96:1455-63
Weiler, S; Kishimoto, Y; O'Brien, J S et al. (1995) Identification of the binding and activating sites of the sphingolipid activator protein, saposin C, with glucocerebrosidase. Protein Sci 4:756-64
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O'Brien, J S; Carson, G S; Seo, H C et al. (1994) Identification of prosaposin as a neurotrophic factor. Proc Natl Acad Sci U S A 91:9593-6
Azuma, N; O'Brien, J S; Moser, H W et al. (1994) Stimulation of acid ceramidase activity by saposin D. Arch Biochem Biophys 311:354-7
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Hiraiwa, M; O'Brien, J S; Kishimoto, Y et al. (1993) Isolation, characterization, and proteolysis of human prosaposin, the precursor of saposins (sphingolipid activator proteins). Arch Biochem Biophys 304:110-6
Ito, K; Takahashi, N; Takahashi, A et al. (1993) Structural study of the oligosaccharide moieties of sphingolipid activator proteins, saposins A, C and D obtained from the spleen of a Gaucher patient. Eur J Biochem 215:171-9

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