We will continue our study of the role of steroid hormones, specifically androgens such as testosterone, in the development and adult function of spinal cord regions controlling masculine copulatory behaviors. By studying a simplified model system, the spinal nucleus of the bulbocavernosus (SNB), which consists of lumbar motoneurons innervating the striated perineal muscles called bulbocavernosus (BC), we can ask fundamental questions about the role of steroid hormones in sculpting the developing nervous system and fine-tuning the adult nervous system to control behavior, especially reproductive behaviors. We will use Cre- lox- technologies in laboratory mice to selectively disable the genes for the androgen receptor (AR) and/or brain-derived neurotrophic factor (BDNF). By disabling such genes in either motoneurons or striated muscle fibers we can ask the site of androgen action for maintaining the system during perinatal development, and for regulating the somata and dendrites of the SNB motoneurons in adulthood, as well as the behavioral capacity of the system. These studies of steroidal regulation of the SNB system may prove relevant to human disorders such as amyotrophic lateral sclerosis (ALS), spinal bulbar muscular atrophy (SBMA) and Shy Drager disease. A characteristic of each of these human disorders is that BC motoneurons are either selectively spared or selectively targeted compared to other motoneurons. Discovering how BC motoneurons are regulated by androgen may reveal why they are selectively vulnerable in human neuromuscular disorders.
We will continue our study of the role of steroid hormones, specifically androgens such as testosterone, in the development and adult function of spinal cord regions controlling behavior. Studying this steroid- sensitive system may afford a better understanding of human disorders such as amyotrophic lateral sclerosis, and spinal bulbar muscular atrophy, in which such steroid-sensitive motoneurons are selectively spared.
|Breedlove, S Marc (2017) Prenatal Influences on Human Sexual Orientation: Expectations versus Data. Arch Sex Behav 46:1583-1592|
|Pfau, Daniel R; Hobbs, Nicholas J; Breedlove, S Marc et al. (2016) Sex and laterality differences in medial amygdala neurons and astrocytes of adult mice. J Comp Neurol 524:2492-502|
|Oki, Kentaro; Halievski, Katherine; Vicente, Laura et al. (2015) Contractile dysfunction in muscle may underlie androgen-dependent motor dysfunction in spinal bulbar muscular atrophy. J Appl Physiol (1985) 118:941-52|
|Halievski, Katherine; Henley, Casey L; Domino, Laurel et al. (2015) Androgen-dependent loss of muscle BDNF mRNA in two mouse models of SBMA. Exp Neurol 269:224-32|
|Puts, David A; Pope, Lauramarie E; Hill, Alexander K et al. (2015) Fulfilling desire: evidence for negative feedback between men's testosterone, sociosexual psychology, and sexual partner number. Horm Behav 70:14-21|
|Renier, Kayla J; Troxell-Smith, Sandra M; Johansen, Jamie A et al. (2014) Antiandrogen flutamide protects male mice from androgen-dependent toxicity in three models of spinal bulbar muscular atrophy. Endocrinology 155:2624-34|
|Chen, Chieh V; Brummet, Jennifer L; Lonstein, Joseph S et al. (2014) New knockout model confirms a role for androgen receptors in regulating anxiety-like behaviors and HPA response in mice. Horm Behav 65:211-8|
|Johnson, Ryan T; Breedlove, S Marc; Jordan, Cynthia L (2013) Androgen receptors mediate masculinization of astrocytes in the rat posterodorsal medial amygdala during puberty. J Comp Neurol 521:2298-309|
|Culbert, Kristen M; Breedlove, S Marc; Sisk, Cheryl L et al. (2013) The emergence of sex differences in risk for disordered eating attitudes during puberty: a role for prenatal testosterone exposure. J Abnorm Psychol 122:420-32|
|Johnson, Ryan T; Schneider, Amanda; DonCarlos, Lydia L et al. (2012) Astrocytes in the rat medial amygdala are responsive to adult androgens. J Comp Neurol 520:2531-44|
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