Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS031911-03
Application #
2269864
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1993-08-01
Project End
1997-07-31
Budget Start
1995-08-01
Budget End
1997-07-31
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Biochemistry
Type
Organized Research Units
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Huai, Qing; Colicelli, John; Ke, Hengming (2003) The crystal structure of AMP-bound PDE4 suggests a mechanism for phosphodiesterase catalysis. Biochemistry 42:13220-6
Dym, Orly; Xenarios, Ioannis; Ke, Hengming et al. (2002) Molecular docking of competitive phosphodiesterase inhibitors. Mol Pharmacol 61:20-5
Atienza, J M; Suh, M; Xenarios, I et al. (2000) Human ERK1 induces filamentous growth and cell wall remodeling pathways in Saccharomyces cerevisiae. J Biol Chem 275:20638-46
Atienza, J M; Susanto, D; Huang, C et al. (1999) Identification of inhibitor specificity determinants in a mammalian phosphodiesterase. J Biol Chem 274:4839-47
Pillai, R; Staub, S F; Colicelli, J (1994) Mutational mapping of kinetic and pharmacological properties of a human cardiac cAMP phosphodiesterase. J Biol Chem 269:30676-81
Pillai, R; Kytle, K; Reyes, A et al. (1993) Use of a yeast expression system for the isolation and analysis of drug-resistant mutants of a mammalian phosphodiesterase. Proc Natl Acad Sci U S A 90:11970-4