Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
7R01NS034761-02
Application #
2038108
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1995-09-30
Project End
1999-09-29
Budget Start
1995-09-30
Budget End
1997-09-29
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Weill Medical College of Cornell University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
201373169
City
New York
State
NY
Country
United States
Zip Code
10065

  Publications

Majumdar, Amitabha; Chung, Haeyong; Dolios, Georgia et al. (2008) Degradation of fibrillar forms of Alzheimer's amyloid beta-peptide by macrophages. Neurobiol Aging 29:707-15
Majumdar, Amitabha; Cruz, Dana; Asamoah, Nikiya et al. (2007) Activation of microglia acidifies lysosomes and leads to degradation of Alzheimer amyloid fibrils. Mol Biol Cell 18:1490-6
Chung, H; Brazil, M I; Irizarry, M C et al. (2001) Uptake of fibrillar beta-amyloid by microglia isolated from MSR-A (type I and type II) knockout mice. Neuroreport 12:1151-4
Brazil, M I; Chung, H; Maxfield, F R (2000) Effects of incorporation of immunoglobulin G and complement component C1q on uptake and degradation of Alzheimer's disease amyloid fibrils by microglia. J Biol Chem 275:16941-7
Chung, H; Brazil, M I; Soe, T T et al. (1999) Uptake, degradation, and release of fibrillar and soluble forms of Alzheimer's amyloid beta-peptide by microglial cells. J Biol Chem 274:32301-8
Paresce, D M; Chung, H; Maxfield, F R (1997) Slow degradation of aggregates of the Alzheimer's disease amyloid beta-protein by microglial cells. J Biol Chem 272:29390-7
Paresce, D M; Ghosh, R N; Maxfield, F R (1996) Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor. Neuron 17:553-65