Mexican Americans are the most numerous sub-group of Hispanic Americans, the largest minority population in the United States. This important group is aging and growing rapidly. For the past 14 years the Brain Attack Surveillance in Corpus Christi (BASIC) Project has provided rich original stroke disparities research comparing Mexican Americans and non-Hispanic whites. BASIC remains the only means to monitor stroke trends and to investigate stroke outcomes in Mexican Americans. BASIC has demonstrated that stroke incidence is higher in Mexican Americans compared with non-Hispanic whites. New stroke incidence data from BASIC show that the disparity remains completely unabated over the last decade. Further, stroke onset occurs at younger ages in Mexican Americans providing more years of disability. This contributes to a substantial increased cost for stroke in Mexican Americans compared with non-Hispanic whites. Remarkable new data from BASIC suggests that the previously seen Mexican American survival advantage post-stroke is disappearing. Further, Mexican American stroke survivors have worse neurologic and functional outcomes. Thus, BASIC data suggests that in 2013 Mexican Americans have more strokes, occurring at younger ages, and experience far greater post- stroke disability than non-Hispanic whites. The current proposal seeks to continue to provide rigorous stroke surveillance to monitor stroke trends in Mexican Americans and non-Hispanic whites. We further propose to provide new longer-term (six month and one year) stroke outcome data to provide crucial information on the time course and changes in neurologic, functional, cognitive, and quality of life outcomes post-stroke in both ethnic groups. Additionally, since post-stroke disability appears much worse in Mexican Americans, we plan to delve deeply into the structure of informal caregiving post-stroke and understand the needs of stroke survivors and the role of families in addressing these needs. This data on the social/family context in which stroke survivors function will be crucial for designing intervention to improve stroke outcome. Finally, the definition of stroke will be studied to understand the impact on measures of stroke burden derived from an ethnically diverse population-based study. BASIC has published over 55 original, peer-reviewed manuscripts, spun-off 5 R-level grants and served as the foundation for training numerous diverse students. In this next cycle, we are poised and deeply committed to provide a fundamental understanding of long-term stroke trends, outcome studies, and informal caregiving structure, as well as continuing to provide key clinical observations such as the impact of the new stroke definition. This work is absolutely critical to Mexican Americans, a growing, aging and large minority population that will increasingly feel the impact from stroke in the next decade. Indeed, this work is also critical to clinicians and public health planners as BASIC continues to offer key observations on stroke and Mexican American health disparities.

Public Health Relevance

This project seeks to monitor and understand the tremendous stroke disparity among Mexican Americans and non-Hispanic whites. Stroke incidence, recurrence, mortality, and, in survivors, neurologic, functional and cognitive outcomes will be compared among the ethnic groups. Informal caregiving structure will be studied to improve services and tailor interventions for stroke survivors and families to improve stroke outcome and prevent second stroke.

National Institute of Health (NIH)
Research Project (R01)
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Neurological, Aging and Musculoskeletal Epidemiology Study Section (NAME)
Program Officer
Waddy, Salina P
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University of Michigan Ann Arbor
Schools of Medicine
Ann Arbor
United States
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Brown, Devin L; Mowla, Ashkan; McDermott, Mollie et al. (2015) Ischemic stroke subtype and presence of sleep-disordered breathing: the BASIC sleep apnea study. J Stroke Cerebrovasc Dis 24:388-93
Burke, James F; Vijan, Sandeep; Chekan, Lynette A et al. (2014) Targeting high-risk employees may reduce cardiovascular racial disparities. Am J Manag Care 20:725-33
Brown, Devin L; McDermott, Mollie; Mowla, Ashkan et al. (2014) Brainstem infarction and sleep-disordered breathing in the BASIC sleep apnea study. Sleep Med 15:887-91
Skolarus, Lesli E; Sanchez, Brisa N; Levine, Deborah A et al. (2014) Association of body mass index and mortality after acute ischemic stroke. Circ Cardiovasc Qual Outcomes 7:64-9
De Lott, Lindsey B; Lisabeth, Lynda D; Sanchez, Brisa N et al. (2014) Prevalence of pre-stroke sleep apnea risk and short or long sleep duration in a bi-ethnic stroke population. Sleep Med 15:1582-5
Zahuranec, Darin B; Lisabeth, Lynda D; Sánchez, Brisa N et al. (2014) Intracerebral hemorrhage mortality is not changing despite declining incidence. Neurology 82:2180-6
Kerber, Kevin A; Zahuranec, Darin B; Brown, Devin L et al. (2014) Stroke risk after nonstroke emergency department dizziness presentations: a population-based cohort study. Ann Neurol 75:899-907
Kelly, Adam G; Zahuranec, Darin B; Holloway, Robert G et al. (2014) Variation in do-not-resuscitate orders for patients with ischemic stroke: implications for national hospital comparisons. Stroke 45:822-7
Brown, Devin L; Chervin, Ronald D; Hegeman 3rd, Garnett et al. (2014) Is technologist review of raw data necessary after home studies for sleep apnea? J Clin Sleep Med 10:371-5
Lisabeth, Lynda D; Sánchez, Brisa N; Baek, Jonggyu et al. (2014) Neurological, functional, and cognitive stroke outcomes in Mexican Americans. Stroke 45:1096-101

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