This competing renewal investigates the role of number knowledge in word meaning. In the prior funding period, we discovered that non-aphasic patients with corticobasal degeneration (CBD) have difficulty with number knowledge, and that this interferes with their comprehension of number-based quantifiers like """"""""at least half"""""""" and """"""""most."""""""" MRI and pathology studies associated this with parietal disease. Converging evidence related quantifier comprehension to parietal activation during fMRI studies of healthy controls. We propose to show that the quantity component of number knowledge is responsible for a specific aspect of number-based quantifier meaning, and studies of CBD and fMRI work in healthy adults will relate this to the intraparietal sulcus. This collaborates with another, pragmatic component of quantifier meaning, and studies of non-aphasic patients with frontal disease due to frontotemporal lobar degeneration (FTLD) and fMRI studies of healthy controls will relate this aspect of quantifier comprehension to prefrontal cortex. Quantifiers can be ambiguous, and a neuroeconomic approach to decision-making will be applied to the interpretation of quantifiers with ambiguous meaning. We will show that evaluating the probability of a specific interpretation is mediated by prefrontal cortex, that appreciating the value of unambiguous communication is related to orbital frontal cortex, and that the integration of these decision-making components is supported by inferior parietal cortex.
In this competing renewal, we propose to show that the quantity component of number knowledge contributes to the representation of number-based quantifiers like """"""""at least half"""""""" and """"""""most."""""""" Studies of patients with corticobasal degeneration and fMRI activation studies of healthy controls will relate this to inferior parietal cortex. This collaborates with another, pragmatic component of quantifiers, and studies of patients with frontotemporal lobar degeneration and fMRI studies of healthy adults will relate this to prefrontal cortex. Quantifiers can be ambiguous, and we will adopt a neuroeconomic approach to decision-making to help understand quantifier interpretation. This process will be mediated by a large-scale neural network including several frontal and parietal regions. The proposed work will provide important insights into the cognitive neuroscience of language and number while improving diagnostic accuracy in an elusive neurodegenerative condition.
|Cousins, Katheryn A Q; York, Collin; Bauer, Laura et al. (2016) Cognitive and anatomic double dissociation in the representation of concrete and abstract words in semantic variant and behavioral variant frontotemporal degeneration. Neuropsychologia 84:244-51|
|Irwin, David J; Brettschneider, Johannes; McMillan, Corey T et al. (2016) Deep clinical and neuropathological phenotyping of Pick disease. Ann Neurol 79:272-87|
|Olm, Christopher A; Kandel, Benjamin M; Avants, Brian B et al. (2016) Arterial spin labeling perfusion predicts longitudinal decline in semantic variant primary progressive aphasia. J Neurol 263:1927-38|
|Irwin, David J; Byrne, Matthew D; McMillan, Corey T et al. (2016) Semi-Automated Digital Image Analysis of Pick's Disease and TDP-43 Proteinopathy. J Histochem Cytochem 64:54-66|
|Healey, Meghan L; Grossman, Murray (2016) Social Coordination in Older Adulthood: A Dual-Process Model. Exp Aging Res 42:112-7|
|Heim, Stefan; McMillan, Corey T; Clark, Robin et al. (2016) How the brain learns how few are ""many"": An fMRI study of the flexibility of quantifier semantics. Neuroimage 125:45-52|
|Grossman, Murray; Irwin, David J (2016) The Mental Status Examination in Patients With Suspected Dementia. Continuum (Minneap Minn) 22:385-403|
|Pustina, Dorian; Coslett, H Branch; Turkeltaub, Peter E et al. (2016) Automated segmentation of chronic stroke lesions using LINDA: Lesion identification with neighborhood data analysis. Hum Brain Mapp 37:1405-21|
|Lee, Yune-Sang; Min, Nam Eun; Wingfield, Arthur et al. (2016) Acoustic richness modulates the neural networks supporting intelligible speech processing. Hear Res 333:108-17|
|Price, Amy Rose; Peelle, Jonathan E; Bonner, Michael F et al. (2016) Causal Evidence for a Mechanism of Semantic Integration in the Angular Gyrus as Revealed by High-Definition Transcranial Direct Current Stimulation. J Neurosci 36:3829-38|
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