Parkinson's disease (PD) is a common age-related neurodegenerative disorder in which multiple aspects of visuospatial cognitive function are impaired. Spatial dysfunction arises from pathological changes in high- order association areas of the brain but also from defective input from lower-level visual processingareas. Deficits in vision are prevalent in PD but virtually nothing is known about the relation between vision, cognition, and daily function in this disorder. Also unknown are the cognitive sequelae of the side of initial motor impairment, despite PD nearly always having unilateral onset of neurodegeneration and unequivocal evidence linking spatial abnormalities to right-hemisphere dysfunction. We propose a multi-level approach to examining visuospatial dysfunction in PD. One major focus is on the visuospatial consequencesof visual deficits, specifically the reduced signal strength that results from contrast sensitivity loss. An innovative aspect of the study is our use of frequency doubling technology and optical coherence tomographyto assess visual (including retinal) function. A second focus is on the side of onset of motor impairment, contralateral o the hemisphere with predominant basal ganglia dysfunction. We plan to conduct control tests of motor- system and prefrontal function to ascertain the extent of independence of the occipital and parietal areas in affecting spatial function in PD. Further, we will conduct an exploration of the relation of visual and visuospatial impairments to daily function as assessed through self-report questionnaires and with an objective open-field measure of gait curvature. Assessmentwill occur at baseline and at one-year follow-up. We propose to examine the ability of 36 patients with left-onset PD (LPD), 36 with right-onset PD (RPD), 36 healthy age-matched adults, and 36 healthy young adults to perform on tests of vision and visuospatial function. Individuals with PD will likely exhibit poorer performance on most tests of vision and visuospatial function than age-matched adults, who in turn will exhibit poorer performance than young adults. We further expect that LPD will show more extensive visuospatial impairments than RPD, and that the pattern of impairments will distinguish the two subgroups. Our tests target visual and visuospatial symptoms reported by the patients themselves, ensuring that the elucidation of mechanisms will have clinical relevance. Demonstration of different profiles of performance in LPD and RPD would bolster arguments of selective visuospatial deficits in PD and suggest differential visual, cognitive, and functional enhancement strategies.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS050446-05
Application #
7799913
Study Section
Special Emphasis Panel (ZRG1-BBBP-H (02))
Program Officer
Sieber, Beth-Anne
Project Start
2006-04-01
Project End
2011-08-31
Budget Start
2010-04-01
Budget End
2011-08-31
Support Year
5
Fiscal Year
2010
Total Cost
$407,522
Indirect Cost
Name
Boston University
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
049435266
City
Boston
State
MA
Country
United States
Zip Code
02215
Seichepine, Daniel R; Neargarder, Sandy; Davidsdottir, Sigurros et al. (2015) Side and type of initial motor symptom influences visuospatial functioning in Parkinson's disease. J Parkinsons Dis 5:75-83
Laudate, Thomas M; Neargarder, Sandy; Cronin-Golomb, Alice (2013) Line bisection in Parkinson's disease: investigation of contributions of visual field, retinal vision, and scanning patterns to visuospatial function. Behav Neurosci 127:151-63
Circelli, Karishma S; Clark, Uraina S; Cronin-Golomb, Alice (2013) Visual scanning patterns and executive function in relation to facial emotion recognition in aging. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 20:148-73
Stavitsky, Karina; Neargarder, Sandy; Bogdanova, Yelena et al. (2012) The impact of sleep quality on cognitive functioning in Parkinson's disease. J Int Neuropsychol Soc 18:108-17
Amick, Melissa M; Miller, Ivy N; Neargarder, Sandy et al. (2012) Web-based assessment of visual and visuospatial symptoms in Parkinson's disease. Parkinsons Dis 2012:564812
Seichepine, Daniel R; Neargarder, Sandy; McCallum, Meaghan E et al. (2012) Luminance affects age-related deficits in object detection: implications for computerized psychological assessments. Psychol Aging 27:522-8
Appleman, Erica R; Stavitsky, Karina; Cronin-Golomb, Alice (2011) Relation of subjective quality of life to motor symptom profile in Parkinson's disease. Parkinsons Dis 2011:472830
Stavitsky, Karina; Cronin-Golomb, Alice (2011) Sleep quality in Parkinson disease: an examination of clinical variables. Cogn Behav Neurol 24:43-9
Seichepine, Daniel R; Neargarder, Sandy; Miller, Ivy N et al. (2011) Relation of Parkinson's disease subtypes to visual activities of daily living. J Int Neuropsychol Soc 17:841-52
Stavitsky, K; Saurman, J L; McNamara, P et al. (2010) Sleep in Parkinson's disease: a comparison of actigraphy and subjective measures. Parkinsonism Relat Disord 16:280-3

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