Stroke is the leading cause of adult disability in the US and a leading cause of death. Mexican Americans (MA), the largest subgroup of Hispanic Americans, have a substantially higher stroke risk than European Americans, especially at younger ages where the risk is more than double. Given the greater risk and earlier onset, the impact of stroke is disproportionately experienced by MAs. Reasons for increased stroke risk in MAs are poorly understood. More than half of ischemic stroke patients have sleep apnea, a very common and important risk factor for stroke and potentially a risk factor for poor stroke outcome. No published studies have established the prevalence of sleep apnea in MAs to discern sleep apnea's contribution to excess stroke burden in this population. Small studies conducted in academic medical centers have suggested that stroke patients with sleep apnea have particularly poor stroke outcomes, but population-based studies in diverse populations are lacking. The current application seeks to investigate health disparities related to sleep apnea in stroke patients in order to understand the marked ethnic differences in stroke. This research will inform the development of interventions to prevent or treat sleep apnea in MAs, which will reduce the ethnic stroke disparity. The parent study for this project, the Brain Attack Surveillance in Corpus Christi (BASIC) project, is an ongoing population-based stroke surveillance study that identifies stroke cases in Nueces County, Texas. This study has made many important discoveries about stroke in Hispanics. BASIC will continue to identify all strokes in Nueces County until mid year 3 of the current application and will provide detailed 90-day stroke outcome data until mid year 2. The current application will extend BASIC data collection through year 5 month 3 and will add: (1) sleep apnea screening in the acute stroke period that differentiates obstructive from central events, (2) sleep apnea screening for intracerebral hemorrhage cases, (3) access to care measures for sleep apnea, and (4) genetic admixture analysis to investigate how genetics may relate to ethnic disparities in sleep apnea. The application seeks, in a cost-containing fashion, to understand and remedy the influence of a very frequent risk factor, sleep apnea, on a common, devastating disease, stroke, in the largest and fastest growing US minority population.

Public Health Relevance

Sleep apnea is an important predictor of stroke and appears to be a predictor of poor outcomes after stroke. Using the preexisting infrastructure of the BASIC project, the current application will provide an assessment of health disparities related to sleep apnea in stroke patients. It will also allow for the rigorous study of ethnic comparisons of sleep apnea after stroke in European Americans and Hispanics, the largest minority in the United States.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS070941-03
Application #
8450206
Study Section
Cardiovascular and Sleep Epidemiology (CASE)
Program Officer
Waddy, Salina P
Project Start
2011-05-01
Project End
2016-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
3
Fiscal Year
2013
Total Cost
$549,596
Indirect Cost
$196,158
Name
University of Michigan Ann Arbor
Department
Neurology
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Brown, Devin L; Mowla, Ashkan; McDermott, Mollie et al. (2015) Ischemic stroke subtype and presence of sleep-disordered breathing: the BASIC sleep apnea study. J Stroke Cerebrovasc Dis 24:388-93
Rundek, Tatjana; Brown, Devin L (2014) Socioeconomic status and subclinical atherosclerosis: are we closing disparity gaps? Stroke 45:948-9
Brown, Devin L; McDermott, Mollie; Mowla, Ashkan et al. (2014) Brainstem infarction and sleep-disordered breathing in the BASIC sleep apnea study. Sleep Med 15:887-91
De Lott, Lindsey B; Lisabeth, Lynda D; Sanchez, Brisa N et al. (2014) Prevalence of pre-stroke sleep apnea risk and short or long sleep duration in a bi-ethnic stroke population. Sleep Med 15:1582-5
Zahuranec, Darin B; Lisabeth, Lynda D; Sánchez, Brisa N et al. (2014) Intracerebral hemorrhage mortality is not changing despite declining incidence. Neurology 82:2180-6
Kerber, Kevin A; Zahuranec, Darin B; Brown, Devin L et al. (2014) Stroke risk after nonstroke emergency department dizziness presentations: a population-based cohort study. Ann Neurol 75:899-907
Woo, Daniel; Falcone, Guido J; Devan, William J et al. (2014) Meta-analysis of genome-wide association studies identifies 1q22 as a susceptibility locus for intracerebral hemorrhage. Am J Hum Genet 94:511-21
Brown, Devin L; Chervin, Ronald D; Hegeman 3rd, Garnett et al. (2014) Is technologist review of raw data necessary after home studies for sleep apnea? J Clin Sleep Med 10:371-5
Lisabeth, Lynda D; Sánchez, Brisa N; Baek, Jonggyu et al. (2014) Neurological, functional, and cognitive stroke outcomes in Mexican Americans. Stroke 45:1096-101
Reeves, Sarah L; Brown, Devin L; Chervin, Ronald D et al. (2014) Agreement between stroke patients and family members for ascertaining pre-stroke risk for sleep apnea. Sleep Med 15:121-4

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