Abstract

Coinfection with HIV and Mycobacterium tuberculosis (M. tb) is associated with high rates of active tuberculosis, and possibly an acceleration of the progression of clinical AIDS. Elucidating the interplay of immunopathogenic events that occur as a result of HIV/M. tb coinfection is, therefore, of central importance for understanding the immune sequlae of this coinfection. The simian immunodeficiency virus (SIV)-infected macaque monkey has proven to be an important model for the study of the pathogenesis and treatment of AIDS. The investigators have recently shown that macaques coinfected with SIV and BCG develop a syndrome similar to AIDS virus-related tuberculosis. Employing this SIV/mycobacterium coinfection model, the immunopathogenesis of AIDS virus interactions with mycobacterium and the evolution of tuberculosis will be evaluated. In these studies, the following will be assessed: I. Disease pathogenesis in SIV/BCG coinfected rhesus monkeys. II. CD4+ responses in BCG-infected and SIV/BCG coinfected monkeys. III. CD8+ responses in BCG-infected and SIV/BCG infected monkeys. IV. T gd+ cell responses in BCG-infected and SIV/BCG coinfected monkeys.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Project (R01)
Project #
5R01RR013601-05
Application #
6540618
Study Section
AIDS and Related Research Study Section 5 (ARRE)
Program Officer
Robinson, Jerry
Project Start
1998-06-01
Project End
2004-05-31
Budget Start
2002-06-01
Budget End
2004-05-31
Support Year
5
Fiscal Year
2002
Total Cost
$434,438
Indirect Cost

  Institution

Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Yang, Rui; Yang, Enzhuo; Shen, Ling et al. (2018) IL-12+IL-18 Cosignaling in Human Macrophages and Lung Epithelial Cells Activates Cathelicidin and Autophagy, Inhibiting Intracellular Mycobacterial Growth. J Immunol 200:2405-2417
Shen, Hongbo; Gu, Jin; Xiao, Heping et al. (2017) Selective Destruction of Interleukin 23-Induced Expansion of a Major Antigen-Specific ?? T-Cell Subset in Patients With Tuberculosis. J Infect Dis 215:420-430
Chen, Zheng W (2016) Protective immune responses of major V?2V?2 T-cell subset in M. tuberculosis infection. Curr Opin Immunol 42:105-112
Zhang, Jun-Ai; Liu, Gan-Bin; Zheng, Bi-Ying et al. (2016) Tuberculosis-sensitized monocytes sustain immune response of interleukin-37. Mol Immunol 79:14-21
Wang, Yang; Zhong, Huiling; Xie, Xiaodan et al. (2015) Long noncoding RNA derived from CD244 signaling epigenetically controls CD8+ T-cell immune responses in tuberculosis infection. Proc Natl Acad Sci U S A 112:E3883-92
Shen, Hongbo; Wang, Yunqi; Chen, Crystal Y et al. (2015) Th17-related cytokines contribute to recall-like expansion/effector function of HMBPP-specific V?2V?2 T cells after Mycobacterium tuberculosis infection or vaccination. Eur J Immunol 45:442-51
Frencher, James T; Shen, Hongbo; Yan, Lin et al. (2014) HMBPP-deficient Listeria mutant immunization alters pulmonary/systemic responses, effector functions, and memory polarization of V?2V?2 T cells. J Leukoc Biol 96:957-67
Yao, Shuyu; Huang, Dan; Chen, Crystal Y et al. (2014) CD4+ T cells contain early extrapulmonary tuberculosis (TB) dissemination and rapid TB progression and sustain multieffector functions of CD8+ T and CD3- lymphocytes: mechanisms of CD4+ T cell immunity. J Immunol 192:2120-32
Chen, Zheng W (2013) Multifunctional immune responses of HMBPP-specific V?2V?2 T cells in M. tuberculosis and other infections. Cell Mol Immunol 10:58-64
Chen, Crystal Y; Yao, Shuyu; Huang, Dan et al. (2013) Phosphoantigen/IL2 expansion and differentiation of V?2V?2 T cells increase resistance to tuberculosis in nonhuman primates. PLoS Pathog 9:e1003501

Showing the most recent 10 out of 59 publications