Binge drinking is prevalent among college students and contributes to serious social and personal problems. A continued pattern of binge drinking poses immediate health risks (e.g., alcohol poisoning, acute alcoholic hepatitis), as well as long- term consequences (alcohol dependence, liver cirrhosis). The proposed research addresses the longstanding question of why some binge drinkers continue to binge drink, despite their attempts to restrain from excessive drinking. The proposed research examines how cognitive impairment produced by a moderate dose of alcohol can compromise a drinker's ability to stop ongoing drinking behavior and contribute to a binge. The study examines young healthy social drinkers between 21 and 30 years old. The research uses a cognitive paradigm to test the degree to which social drinkers can control and inhibit their behavior under a moderate dose of alcohol administered in the laboratory. Individual differences in the degree to which alcohol impairs this ability are examined in relation to drinker's self-reports of binge drinking, and other risk factors, such as their level of subjective reinforcement from alcohol, and their level of preoccupation with controlling drinking. The research will determine whether the propensity to binge drink is greater is greater among individuals who suffer more impairment of behavioral control from a dose of alcohol. The research also will show how alcohol impairment of self-control can represent an abuse liability factor that differs from traditional abuse liability measures that are based on self-reported levels of subjective intoxication and reinforcement. The long-term objective of this research is to determine how individual differences in alcohol impairment of cognitive functioning can represent an early-onset risk factor for later alcohol dependence by promoting a continued pattern of abusive binge drinking.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Small Research Grants (R03)
Project #
5R03AA012738-02
Application #
6371653
Study Section
Special Emphasis Panel (ZAA1-AA (02))
Program Officer
Witt, Ellen
Project Start
2000-07-01
Project End
2002-06-30
Budget Start
2001-07-01
Budget End
2002-06-30
Support Year
2
Fiscal Year
2001
Total Cost
$72,400
Indirect Cost
Name
University of Kentucky
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
939017877
City
Lexington
State
KY
Country
United States
Zip Code
40506
Fillmore, Mark T; Blackburn, Jaime (2002) Compensating for alcohol-induced impairment: alcohol expectancies and behavioral disinhibition. J Stud Alcohol 63:237-46
Fillmore, M I; Rush, C R (2001) Alcohol effects on inhibitory and activational response strategies in the acquisition of alcohol and other reinforcers: priming the motivation to drink. J Stud Alcohol 62:646-56
Fillmore, M T; Rush, C R; Kelly, T H et al. (2001) Triazolam impairs inhibitory control of behavior in humans. Exp Clin Psychopharmacol 9:363-71
Vogel-Sprott, M; Easdon, C; Fillmore, M et al. (2001) Alcohol and behavioral control: cognitive and neural mechanisms. Alcohol Clin Exp Res 25:117-21
Fillmore, M T; Kelly, T H; Rush, C R et al. (2001) Retrograde facilitation of memory by triazolam: effects on automatic processes. Psychopharmacology (Berl) 158:314-21
Fillmore, M T (2001) Cognitive preoccupation with alcohol and binge drinking in college students: alcohol-induced priming of the motivation to drink. Psychol Addict Behav 15:325-32
Fillmore, M T; Dixon, M J; Schweizer, T A (2000) Differential effects of alcohol on responses to negatively and positively primed stimuli. J Stud Alcohol 61:872-80