In this proposal, we plan to use a Complex Systems Biology approach to characterize the global microbiome and metabolome of various wounds over a longitudinal period of time. In addition, these global profiles will be integrated with an analysis of innate immune potential for activation. The research proposed here has the potential to uncover how the microbiome and innate immune responses influence the wound metabolic landscape and to generate insights into novel, low-cost therapeutic interventions that exploit microbial metabolic pathways or host cell metabolic immunomodulation changes. The ultimate goal is to develop evidence-based, medical countermeasure protocols that could be initiated in the clinic and followed by an outpatient population. By 2050, the American Diabetes Foundation predicts that one in three adults in the United States will have diabetes, correlating to a significant immunocompromised population and nearly 85 million patients subjected to loss of a limb as a result of a non-healing chronic wound. With this research, we will not only gain significant insight in to the basic biology of host-pathogen interactions within the chronic wound environment in diabetics, but will also lay the foundation for novel medical interventions predictive of wound healing.

Public Health Relevance

In the United States, we are experiencing an epidemic of diabetes. Treatment of diabetic- associated chronic wounds is a major socioeconomic burden with an estimated $58 billion in medical costs associated with treatment. With nearly 25% of diabetic patients subject to limb amputation as a result of ineffective treatment for chronic wounds, there is a need for better understanding of wound healing in diabetics and development of novel, evidence-based treatment protocols.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Small Research Grants (R03)
Project #
5R03AI135998-02
Application #
9647416
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Program Officer
Esch, Thomas R
Project Start
2018-02-14
Project End
2021-01-31
Budget Start
2019-02-01
Budget End
2021-01-31
Support Year
2
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Idaho Veterans Research / Education Fdn
Department
Type
DUNS #
078355532
City
Boise
State
ID
Country
United States
Zip Code
83702