Gestational diabetes mellitus (GDM) complicates approximately 7% of pregnancies in the U.S. However, the epidemics of obesity and diabetes, as well as revised GDM diagnostic criteria, are dramatically increasing the prevalence of GDM, as high as 18% of pregnancies according to some estimates. This increasing prevalence is noteworthy because of the concomitant risk for adverse sequelae, not only in the peripartum period, such as increased rates of caesarean section delivery and neonatal birth injury, but also subsequent to pregnancy, including increased risk for type 2 diabetes mellitus (T2DM) for both mother and offspring. Early identification of women at increased risk for GDM would provide the opportunity for the development of targeted GDM and T2DM risk prevention strategies. Our proposal capitalizes on our expertise in emerging technologies, as well as our existing study populations, to further characterize women at increased risk for developing GDM and T2DM.
Our Specific Aim 1 will examine a cohort of women followed during pregnancy for the development of GDM.
Our Specific Aims 2 -4 will examine the cohort of women within the Diabetes Prevention Program (DPP) with a history of GDM for the development of T2DM while examining the effects of study intervention and race on the outcome.

Public Health Relevance

Our proposal has significant public health implications as it focuses on identifying women at increased risk for gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM). We will use ground- breaking technology to identify these women so that we may best direct efforts to reduce the burden of GDM and T2DM.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Small Research Grants (R03)
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Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Mcbryde, Kevin D
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Massachusetts General Hospital
United States
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Bentley-Lewis, Rhonda; Huynh, Jennifer; Li, Sylvia et al. (2016) Hypertension Risk Subsequent to Gestational Dysglycemia Is Modified by Race/Ethnicity. Hypertension 67:223-8
Huynh, Jennifer; Yamada, Jessica; Beauharnais, Catherine et al. (2015) Type 1, type 2 and gestational diabetes mellitus differentially impact placental pathologic characteristics of uteroplacental malperfusion. Placenta 36:1161-6
Huynh, J; Dawson, D; Roberts, D et al. (2015) A systematic review of placental pathology in maternal diabetes mellitus. Placenta 36:101-14
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Bentley-Lewis, Rhonda; Huynh, Jennifer; Xiong, Grace et al. (2015) Metabolomic profiling in the prediction of gestational diabetes mellitus. Diabetologia 58:1329-32
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Bentley-Lewis, R; Xiong, G; Lee, H et al. (2014) Metabolomic Analysis Reveals Amino Acid Responses to an Oral Glucose Tolerance Test in Women with Prior History of Gestational Diabetes Mellitus. J Clin Transl Endocrinol 1:38-43
Huynh, Jennifer; Xiong, Grace; Bentley-Lewis, Rhonda (2014) A systematic review of metabolite profiling in gestational diabetes mellitus. Diabetologia 57:2453-64
Bentley-Lewis, Rhonda; Powe, Camille; Ankers, Elizabeth et al. (2014) Effect of race/ethnicity on hypertension risk subsequent to gestational diabetes mellitus. Am J Cardiol 113:1364-70