Adipose tissue distribution is an important determinant of obesity-related comorbidities. Peripheral obesity (subcutaneous/gluteofemoral adipose tissue accumulation) is associated with improved insulin sensitivity and lower risk for metabolic co-morbidities such as dyslipidemia, cardiovascular disease, insulin resistance and type-2-diabetes. It has been postulated that the protective effects of peripheral adipose tissue occur via its ability to sequester surplus lipid and thus serve as a "metabolic sink". We propose to systematically examine how peripheral adipose tissue serves a protective role in obesity using a model in which various amounts of peripheral adipose tissue are removed. In support of this, removal of peripheral adipose tissue leads to impaired glucose tolerance and tissue-specific lipid accumulation in mice.
Aim 1 investigates the role of peripheral adipose tissue in glucose homeostasis.
Aim 2 will examine how peripheral adipose tissue removal leads to impaired glucose tolerance. Overall, completion of these aims will provide new insight into how peripheral adipose tissue regulates glucose homeostasis. Results from these studies will fundamentally advance the field of adipose tissue biology and increase our understanding of potential therapeutic strategies for obesity prevention and treatment.

Public Health Relevance

Central obesity is a risk factor for many adverse metabolic outcomes such as dyslipidemia, cardiovascular disease, insulin resistance and type-2-diabetes, while peripheral obesity is associated with improved insulin sensitivity and lower risk for these adverse outcomes. This project attempts to determine why peripheral adipose tissue is linked to improved insulin sensitivity.

Agency
National Institute of Health (NIH)
Type
Small Research Grants (R03)
Project #
1R03DK099425-01A1
Application #
8702535
Study Section
Digestive Diseases and Nutrition C Subcommittee (DDK)
Program Officer
Hyde, James F
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Colorado State University-Fort Collins
Department
Nutrition
Type
Sch of Home Econ/Human Ecology
DUNS #
City
Fort Collins
State
CO
Country
United States
Zip Code
80521