Support is requested for a Keystone Symposia meeting entitled Cellular Stress Responses and Infectious Agents, organized by Drs. Margo A. Brinton, Sandra K. Weller and Beth Levine. The meeting will be held in Santa Fe, New Mexico from December 4-8, 2016. This conference will bring together researchers studying various cellular stress responses and researchers interested in how various infectious agents activate and manipulate host cellular stress responses. Examples of cellular stress responses activated by infectious agents are: the stress granule response, the unfolded protein response, the DNA damage response, responses to oxidative stress and metabolic stress, autophagy, and other protein quality control responses. Many of these cellular homeostatic mechanisms function as part of innate and intrinsic defense mechanisms to counteract infections. Various infectious agents have evolved to subvert and manipulate many of these anti- pathogen mechanisms by utilizing, evading or inactivating components of these cellular pathways. The study of interactions between infectious agents and these pathways provides new insights about cellular stress responses and identifies new targets for the development of novel therapies for the treatment of infectious diseases. The general topic of this meeting is relevant to the NIAID mission with respect to its mission of understanding and treating infectious diseases. Specifically, studies of cell stress responses and how these responses are utilized and/or counteracted by an infectious agent will lead to a better understanding of cell-pathogen interactions.

Public Health Relevance

The cellular proteome is constantly exposed to a wide variety of stresses, and cellular protein homeostasis is maintained by strictly controlled protein quality control and stress protection mechanisms. Alterations in these mechanisms result in diseases such as cancer, cardiovascular disease, metabolic disease, liver disease or aging-related protein aggregation diseases such as Alzheimer?s disease. Studies of the interactions between infectious agents and cellular stress response pathways not only provide new insights about cellular stress responses but also identify new targets for the development of novel therapies for the treatment of infectious diseases. The Keystone Symposia meeting on Cellular Stress Responses and Infectious Agents will bring together cell biologists studying various cellular stress responses and researchers interested in how various infectious agents activate and manipulate host cellular stress responses.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Conference (R13)
Project #
1R13AI126782-01
Application #
9194937
Study Section
Special Emphasis Panel (ZAI1)
Program Officer
Miller, Lara R
Project Start
2016-11-10
Project End
2017-10-31
Budget Start
2016-11-10
Budget End
2017-10-31
Support Year
1
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Keystone Symposia
Department
Type
DUNS #
079780750
City
Silverthorne
State
CO
Country
United States
Zip Code
80498