The conference, """"""""Finding a Research Path for the Identification of Biomarkers of Sleepiness"""""""" will be a 1.5 meeting of world-renown experts in sleep deprivation research, proteomics, genomics and related fields who are being convened to discuss what is known concerning potential biomarkers of sleepiness and to develop a research pathway towards identifying clinically and research usable biomarkers of sleepiness. To these ends, the objectives of this conference are the following: 1. Provide an overview of the utility of current instruments to detect and quantify levels of sleepiness including both subjective and objective tools or techniques;2. Present current research on the use of genomic, proteomic and molecular approaches to assess sleepiness with the emphasis on how such techniques might be used clinically or for clinical research;3. Stimulate research into the development of clinically useful biomarkers of sleepiness by formulating a research pathway for investigators to follow. The conference will be sponsored by the Harvard Medical School, Division of Sleep Medicine and held on September 21-22, 2010 in Boston, MA. During these 1.5 days, international and national scholars will give presentations and participate in panel discussions focused in 3 areas: 1) Current Instruments to Assess Sleepiness;2) Genomic, Proteomic and Molecular Markers of Sleepiness;and 3) Developing a Biomarker of Sleepiness. We expect to have an audience of approximately 100 participants consisting of a cross-disciplinary mixture of senior and more junior investigators, sleep researchers and investigators from other fields, and interested parties from industry. The proceedings will be published in a journal indexed in PubMed and a link to the proceedings will be posted on the Division of Sleep Medicine website.

Public Health Relevance

The conference on """"""""Finding a Research Path for the Identification of Biomarkers of Sleepiness"""""""" will be held on September 21-22, 2009 in Boston, MA. The overall objective of this conference is to develop research pathways for investigators to follow so that a clinically and research useful biomarker to quantify and detect sleepiness can be developed. Such a biomarker will have important utility in reducing the public health and economic consequences of sleepiness.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Conference (R13)
Project #
1R13HL104874-01
Application #
8006185
Study Section
Special Emphasis Panel (ZHL1-CSR-W (M2))
Program Officer
Lewin, Daniel S
Project Start
2010-07-01
Project End
2012-06-30
Budget Start
2010-07-01
Budget End
2012-06-30
Support Year
1
Fiscal Year
2010
Total Cost
$20,000
Indirect Cost
Name
Harvard University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
047006379
City
Boston
State
MA
Country
United States
Zip Code
02115
Mullington, Janet M; Czeisler, Charles A; Goel, Namni et al. (2011) Panel discussion: current status of measuring sleepiness. J Clin Sleep Med 7:S22-5
Thimgan, Matthew S; Duntley, Stephen P; Shaw, Paul J (2011) Changes in gene expression with sleep. J Clin Sleep Med 7:S26-7
Quan, Stuart F (2011) Finding a research path for the identification of biomarkers of sleepiness. J Clin Sleep Med 7:S4-5
Davis, Christopher J; Clinton, James M; Jewett, Kathryn A et al. (2011) Delta wave power: an independent sleep phenotype or epiphenomenon? J Clin Sleep Med 7:S16-8
Albert, Michelle A (2011) Biomarkers and heart disease. J Clin Sleep Med 7:S9-11
Naidoo, Nirinjini (2011) Potential of proteomics as a bioanalytic technique for quantifying sleepiness. J Clin Sleep Med 7:S28-30
Balkin, Thomas J (2011) Behavioral biomarkers of sleepiness. J Clin Sleep Med 7:S12-5
Carpagnano, Giovanna E (2011) Exhaled breath analysis and sleep. J Clin Sleep Med 7:S34-7
Czeisler, Charles A (2011) Impact of sleepiness and sleep deficiency on public health--utility of biomarkers. J Clin Sleep Med 7:S6-8
Church, George M (2011) New technologies for integrating genomic, environmental and trait data. J Clin Sleep Med 7:S43-4

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