Underage drinking is a major public health concern, showing disproportionately harmful effects on African Americans. Despite the fact that African-American youth exhibit higher rates of abstinence and lower rates of binge drinking, African-American drinkers experience more negative consequences from drinking such as more negative family and interpersonal problems, legal problems, alcohol-related injuries and diseases, and alcohol dependence symptoms. In addition, once developed, alcohol problems are more likely to persist in African American drinkers than in other racial groups. To reduce these troubling alcohol-related health disparities, it is essential to better understand the risk pathways involved in escalations of alcohol use and negative drinking consequences (e.g., academic failure, involvement with the criminal justice system, substance use, and risky sexual behaviors) among African Americans. Mid-adolescence is the optimal period to observe escalations of alcohol use and negative drinking consequences and their risk processes, because alcohol initiation peaks at ages 12/13 and alcohol use disorders peaks at age 18. In the dynamic interactionism perspective, individuals develop through the ongoing reciprocal interplay with their social environment. Although a wide range of individual and social environmental risk factors have been identified, it is unknown how these factors reciprocally affect each other and shape changes in alcohol use and negative drinking consequences among African-American youth over time. Using a genetically-informed 2-wave longitudinal study design, this proposed research aims to model two pathways (i.e., self-selection and gene- environment interaction), by which individual factors interplay with social environmental factors and affect increases in alcohol use and consequences among urban African American youth. First, individual factors (e.g., prior drinking, impulsivity, intention to drink, and the DRD4 rs1800955) that determine the extent to which youth select into high-risk environments (e.g., heavy-drinking peers, and easy alcohol accessibility) will be identified. Second, the extent to which genotypes (the 5-HTTLPR, the DRD4 VNTR, the DRD4 rs1800955, and the ADH1B*3) modulate environmental influences on changes in alcohol use and consequences over time will be tested. The two processes of self-selection and gene-environment interactions will elucidate critical pathways by which alcohol use and consequences are exacerbated over time. The enhanced knowledge about the risk pathways among African American youth will improve public health by informing the development of ethnically and developmentally sensitive prevention and intervention strategies designed to reduce health disparities related to alcohol among African American youth.

Public Health Relevance

This study aims to identify individual and social environmental risk factors for alcohol use and consequences among Black/African American youth. Results from this study will inform ethnically-sensitive prevention and treatment strategies to reduce alcohol use and related negative consequences among Black/African American youth.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Academic Research Enhancement Awards (AREA) (R15)
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Special Emphasis Panel (ZRG1-RPHB-R (80))
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Scott, Marcia S
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Syracuse University
Schools of Arts and Sciences
United States
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Zaso, Michelle J; Desalu, Jessica M; Kim, Jueun et al. (2018) Interaction between the ADH1B*3 allele and drinking motives on alcohol use among Black college students. Am J Drug Alcohol Abuse 44:329-338
Desalu, Jessica M; Kim, Jueun; Zaso, Michelle J et al. (2017) Racial discrimination, binge drinking, and negative drinking consequences among black college students: serial mediation by depressive symptoms and coping motives. Ethn Health :1-15
Park, Aesoon; Kim, Jueun; Zaso, Michelle J et al. (2017) The interaction between the dopamine receptor D4 (DRD4) variable number tandem repeat polymorphism and perceived peer drinking norms in adolescent alcohol use and misuse. Dev Psychopathol 29:173-183
Zaso, Michelle J; Maisto, Stephen A; Glatt, Stephen J et al. (2017) Interaction Between the ?-Opioid Receptor Gene and the Number of Heavy-Drinking Peers on Alcohol Use. Alcohol Clin Exp Res 41:2041-2050
Goodhines, Patricia A; Gellis, Les A; Kim, Jueun et al. (2017) Self-Medication for Sleep in College Students: Concurrent and Prospective Associations With Sleep and Alcohol Behavior. Behav Sleep Med :1-15
Park, Aesoon; Eckert, Tanya L; Zaso, Michelle J et al. (2017) Associations Between Health Literacy and Health Behaviors Among Urban High School Students. J Sch Health 87:885-893
Desalu, Jessica M; Zaso, Michelle J; Kim, Jueun et al. (2017) Interaction between ADH1B*3 and alcohol-facilitating social environments in alcohol behaviors among college students of african descent. Am J Addict 26:349-356
Zaso, Michelle J; Park, Aesoon; Kim, Jueun et al. (2016) The associations among prior drinking consequences, subjective evaluations, and subsequent alcohol outcomes. Psychol Addict Behav 30:367-76
Zaso, Michelle J; Park, Aesoon; Antshel, Kevin M (2015) Treatments for Adolescents With Comorbid ADHD and Substance Use Disorder: A Systematic Review. J Atten Disord :