Early-stage diagnosis of breast cancer is essential for improving the survival rate of women affected (1 in 8) in the United States. Near-infrared (NIR) optical imaging is a non-invasive and non-ionizing modality that is emerging as a diagnostic tool for breast cancer. In recent years, hand-held based optical imagers developed towards clinical translation of the technology are not capable of contouring along tissue curvatures, nor perform three-dimensional (3D) tomographic imaging to diagnose deep and/or early stage tumors. The overall objective of the proposed work is to implement the recently developed portable cart-based hand-held optical imager for tissue phantom and in-vivo breast imaging studies (in normal and breast cancer subjects), in order to demonstrate near-real time 2D tumor detection and 3D tomographic analysis, towards breast cancer diagnosis.
The specific aims i nclude: (i) Demonstrate real-time simultaneous bilateral breast imaging in tissue phantoms and in-vivo, using a novel hand-held optical imager, in order to detect tumor-mimicking targets in near real-time. (ii) Demonstrate the feasibility of 3D target localization in tissue phantoms and in-vivo, via 3D tomographic imaging studies using the hand-held optical imager;and (iii) Determine the effectiveness of tumor detection in breast cancer subjects using the hand-held optical imager, in comparison to the gold-standard x- ray mammography. The hypothesis of the application relies on a three-fold innovative implementation: (i) the """"""""forked"""""""" probe design aids in performing simultaneous bilateral imaging of both the breast tissues, in order to improve the signal-to-noise (SNR) ratio between the normal and diseased tissue;(ii) co-registered measurements using a hand-held probe on any tissue volume and curvature aids in near real-time target detections as well as 3D tomographic imaging;and (iii) simultaneous illumination and detection at multiple locations on the tissue will allow rapid imaging time, appropriate for a clinical environment. The study design involves the following: (i) Perform simultaneous bilateral imaging on breast phantoms, in-vivo on healthy and breast cancer subjects to determine the effectiveness of 2D target (tumor) detectability with maximum SNR. (ii) Implement a coregistered imaging approach to obtain positional information of the probe(s) towards 3D tomographic analysis in phantom and in-vivo. (iii) Determine the 3D target (tumor) location(s) via tomographic analysis in phantoms and in-vivo;and (iv) Compare the optical images to the gold standard x-ray mammography images in breast cancer subject studies, in order to assess the feasibility of the hand-held optical imager in a clinical environment. The proposed research significantly impacts by accelerating the clinical translation of the emerging optical imaging technology towards early-stage breast cancer diagnosis, due to the unique and innovative method of 3D target localization using a portable and inexpensive hand-held optical imager. The technology also has potential towards prognostic breast imaging, image-guided breast cancer therapy, and volumetric analysis of tumors in response to chemotherapeutic trials.
The portable hand-held optical imager with its capabilities of 2D near real-time surface imaging and 3D tomographic analysis has potential for early-stage diagnostic/prognostic breast imaging in younger women and/or women with dense breasts.
|Erickson-Bhatt, Sarah J; Roman, Manuela; Gonzalez, Jean et al. (2015) Noninvasive Surface Imaging of Breast Cancer in Humans using a Hand-held Optical Imager. Biomed Phys Eng Express 1:|
|Godavarty, Anuradha; Rao, P N Someshwara; Khandavilli, Yamini et al. (2015) Diabetic Wound Imaging Using a Noncontact Near-Infrared Scanner: A Pilot Study. J Diabetes Sci Technol 9:1158-9|
|Chaudhary, Ujwal; Hall, Michael; Gonzalez, Jean et al. (2014) Motor response investigation in individuals with cerebral palsy using near infrared spectroscopy: pilot study. Appl Opt 53:503-10|
|Erickson, Sarah J; Martinez, Sergio L; DeCerce, Joseph et al. (2013) Three-dimensional fluorescence tomography of human breast tissues in vivo using a hand-held optical imager. Phys Med Biol 58:1563-79|
|Roman, Manuela; Gonzalez, Jean; Carrasquilla, Jennifer et al. (2013) Resolution of a Gen-2 handheld optical imager: diffuse and fluorescence imaging studies. Appl Opt 52:8060-6|
|Gonzalez, Jean; Roman, Manuela; Hall, Michael et al. (2012) Gen-2 hand-held optical imager towards cancer imaging: reflectance and transillumination phantom studies. Sensors (Basel) 12:1885-97|
|Gonzalez, Jean; Decerce, Joseph; Erickson, Sarah J et al. (2012) Hand-held optical imager (Gen-2): improved instrumentation and target detectability. J Biomed Opt 17:081402-1|
|Erickson, Sarah J; Martinez, Sergio L; Gonzalez, Jean et al. (2010) Improved detection limits using a hand-held optical imager with coregistration capabilities. Biomed Opt Express 1:126-134|
|Ge, Jiajia; Erickson, Sarah J; Godavarty, Anuradha (2010) Multi-projection fluorescence optical tomography using a handheld-probe-based optical imager: phantom studies. Appl Opt 49:4343-54|
|Ge, Jiajia; Erickson, Sarah J; Godavarty, Anuradha (2009) Fluorescence tomographic imaging using a handheld-probe-based optical imager: extensive phantom studies. Appl Opt 48:6408-16|
Showing the most recent 10 out of 11 publications