Although it is well-established that alcohol and tobacco use are linked, relatively little is known about the nature of the relationship, as most research has focused on one substance or the other. The purpose of the present study is to explore potential differences at different stages of SATU in terms of risk factors and reactivity t environmental substance cues and to develop a measure of motives and expectancies for simultaneous use of alcohol and tobacco (SATU). Utilizing items drawn from existing alcohol- and tobacco-specific measures and [previously tested in focus group discussions], we will develop a measure of motives and expectancies for alcohol SATU. Next, we will recruit 18-25 year olds (n = 300) from the community. Subjects will be divided evenly into four groups based on current alcohol and tobacco use: heavy/heavy, heavy/light, light/heavy, and light/light. Subjects will be enrolled and complete the new measure as well as assessment of a number of risk factors online. Finally, 60 subjects (15 from each group, matched on age, sex, race/ethnicity) will be selected to participate in an fMRI session in which they will be exposed to alcohol, tobacco, [and SATU] cues. Cue reactivity will be measured in terms of brain activity and self-reported craving for alcohol and tobacco. Psychometric properties of the new measure of co-use motives and expectancies will be assessed via exploratory [and confirmatory] factor analysis. We anticipate several distinct but related factors, including enhancement, automaticity, and social/conformity motives. We will also evaluate the validity of the new scale by comparing scores among the groups, and correlating scores with the assessed risk factors. We hypothesize that the two heavy alcohol use groups will exhibit the most positive expectancies and strongest motives for co-use, followed by the two light alcohol groups. It is also expected that scores will be significantly correlated with frequency of SATU and with several risk factors for substance use. Finally, we predict that both heavy alcohol groups will report more positive expectancies for SATU than for either substance alone, and that their expectancies for SATU will be more positive than the other groups. In terms of the fMRI task, we expect that heavy alcohol users will exhibit greater BOLD and craving reactivity to alcohol-only cues compared with others. We also hypothesize that heavier co-users will exhibit cross-reactivity, such that alcohol-only cues elicit tobacco as well as alcohol craving, and vice versa. Finally, we expect that SATU cues will elicit greater BOLD and craving responses than alcohol-only cues in those who report frequent simultaneous use.

Public Health Relevance

Although there has been little systematic examination of the simultaneous use of alcohol and tobacco, the evidence that does exist suggests that the effects of alcohol and tobacco may be more powerful when they are used together. The purpose of the current proposal is to examine young adults'motives for using both substances and to identify risk factors for and patterns of co-use of alcohol and tobacco as a first step toward a line of research assessing risk for and consequences of co-use over time. We propose to recruit a sample of 300 18-25 year-olds from the community to complete an online assessment, and to choose a subsample of 60 to participate in neurocognitive laboratory assessment of their reactions to alcohol- and tobacco- related pictures.

Agency
National Institute of Health (NIH)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21AA021822-02
Application #
8733113
Study Section
Biomedical Research Review Subcommittee (AA)
Program Officer
Matochik, John A
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Psychiatry
Type
Schools of Medicine
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92093