Abstract

The goal of these studies is to determine whether adult human thymuses remain active and capable of generating new T cells in drug-treated HIV- infected individuals. Experiments detailed in this application are designed 1) to determine the potential of adult-derived human thymic stroma and CD34+ cells to support thymopoiesis in vivo in the SCID-hu mouse and to identify means of enhancing that potential, and 2) to assess the impact of HIV-1 on the ability of human adult thymic stroma and CD34+ cells to support thymopoiesis in vivo.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21AG016825-02
Application #
6077833
Study Section
Special Emphasis Panel (ZRG5-AARR-2 (03))
Project Start
1998-09-30
Project End
2000-09-29
Budget Start
1999-09-30
Budget End
2000-09-29
Support Year
2
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Jamieson, B D; Douek, D C; Killian, S et al. (1999) Generation of functional thymocytes in the human adult. Immunity 10:569-75