The objective of the current project is to develop new drug therapies to treat cognitive dysfunction associated with Alzheimer's disease. The goal is to treat symptoms such as memory impairment but also to delay the onset of the brain dysfunction that underlies this cognitive decline. The proposed experiments aim to demonstrate the efficacy of a novel muscarinic M1-specific agonist (VU0364572) in treating hippocampal dysfunction in a rat model of Alzheimer's disease. The approach will focus on in vivo electrophysiological recordings of many individual hippocampal neurons as a sensitive assay of memory functioning. In addition, the proposed experiments aim to demonstrate the efficacy of VU0364572 in delaying the onset of memory impairments and brain pathology in a rat model of Alzheimer's disease. Over the two- year period, the proposed experiments are expected to contribute to the training of one graduate student and two undergraduate students.

Public Health Relevance

The objective of the current project is to develop new drug therapies to treat cognitive dysfunction associated with Alzheimer's Disease. The goal is to treat symptoms such as memory impairment but also to delay the onset of the brain dysfunction that underlies this cognitive decline.

Agency
National Institute of Health (NIH)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21AG042730-02
Application #
8699638
Study Section
(DDNS)
Program Officer
Refolo, Lorenzo
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Emory University
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Galloway, Claire R; Lebois, Evan P; Shagarabi, Shezza L et al. (2014) Effects of selective activation of M1 and M4 muscarinic receptors on object recognition memory performance in rats. Pharmacology 93:57-64