The goal of the proposed research is to establish methods for generating artificial epidermis for replacement therapies. Specifically, this project aims to determine the conditions to obtain skin grafts that include its normal appendages;the sebaceous glands and hair follicles. We have generated a novel method for culturing human primary sebaceous gland cells that maintain all the characteristics of sebocytes in vitro. The current project reflects an exciting new direction stemming directly from this work as we wish to use this technique to generate sebaceous gland in artificial epidermis.

Public Health Relevance

We have generated a novel method for culturing human primary sebaceous gland cells that maintain all the characteristics of sebocytes in vitro. The current project reflects an exciting new direction stemming directly from this work as we wish to use this technique to generate sebaceous gland in artificial epidermis.

Agency
National Institute of Health (NIH)
Type
Exploratory/Developmental Grants (R21)
Project #
1R21AR064341-01A1
Application #
8698511
Study Section
Musculoskeletal Tissue Engineering Study Section (MTE)
Program Officer
Baker, Carl
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2014
Total Cost
Indirect Cost
City
Cincinnati
State
OH
Country
United States
Zip Code
45229