It is proposed a randomized, blinded, controlled trial comparing vestibular rehabilitation (VR) to Tai Chi. Our overall goal is to explore whether, and if so, how TC can improve functional, dynamic stability in persons with vestibulopathy (VSP). It is hypothesized that the TC group will demonstrate significantly greater improvement in performing functional activities than the VR group.
Specific Aims #1 : To determine the relative neuro-biomechanical benefits of TC and VR. Sixty subjects will be randomly assigned into either TC instruction or VR. Both treatment groups will receive identical duration treatment once a week for 10 weeks, with supplemental home exercises. It is hypothesized that I) TC improves whole-body dynamic locomotor stability more than does VR; 2) TC improves gait coordination during planned and unplanned obstacle encounters more than does VR; 3) TC improves whole-body speed related movement control more than does VR. #2: To determine which biomechanical measures best demonstrate TC and VR motor control and coordination improvements. It is proposed to quantify VSP patients' motor control and coordination using muscle power flow, gaze (eyehead) stability, and whole-body dynamic stability during standing, locomotion and balance perturbations. It is hypothesized that 1) The TC group will demonstrate power flow more similar to healthy individuals than those receiving VIA during locomotion and balance recovery followingperturbation; 2) The TC group will demonstrate greater improvements in intersegmental movement coordination, which in turn, translates into improved gaze and whole-body stability, than the VR group. #3: A) To determine whether TC improves psychological status, including fear of falling. B) To determine the association between both psychological variables and TCM medical diagnosis, and their predictive value about response to TC or VR. It is hypothesized that TC will improve both fear of falling and other psychological scores more than VR. It will also be diagnosed each patient according to traditional Chinese medicine (TCM) diagnostic categories to determine whether any TCM category is more likely to be associated with improvements in either group. The latter aim is purely exploratory and descriptive in nature.

Agency
National Institute of Health (NIH)
Institute
National Center for Complementary & Alternative Medicine (NCCAM)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21AT000553-02
Application #
6512102
Study Section
Special Emphasis Panel (ZAT1-C (07))
Program Officer
Glowa, John R
Project Start
2001-05-01
Project End
2003-03-31
Budget Start
2002-04-15
Budget End
2003-03-31
Support Year
2
Fiscal Year
2002
Total Cost
$216,250
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Wayne, Peter M; Scarborough, Donna Moxley; Krebs, David E et al. (2005) Tai Chi for vestibulopathic balance dysfunction: a case study. Altern Ther Health Med 11:60-6
McGibbon, Chris A; Krebs, David E; Parker, Stephen W et al. (2005) Tai Chi and vestibular rehabilitation improve vestibulopathic gait via different neuromuscular mechanisms: preliminary report. BMC Neurol 5:3
Cavanaugh, James T; Goldvasser, Dov; McGibbon, Chris A et al. (2005) Comparison of head- and body-velocity trajectories during locomotion among healthy and vestibulopathic subjects. J Rehabil Res Dev 42:191-8
McGibbon, Chris A; Krebs, David E; Wolf, Steven L et al. (2004) Tai Chi and vestibular rehabilitation effects on gaze and whole-body stability. J Vestib Res 14:467-78
McGibbon, Chris A; Goldvasser, Dov; Krebs, David E et al. (2004) Instant of chair-rise lift-off can be predicted by foot-floor reaction forces. Hum Mov Sci 23:121-32
Wayne, Peter M; Krebs, David E; Wolf, Steven L et al. (2004) Can Tai Chi improve vestibulopathic postural control? Arch Phys Med Rehabil 85:142-52
Oddsson, Lars I E; Wall, Conrad; McPartland, Michael D et al. (2004) Recovery from perturbations during paced walking. Gait Posture 19:24-34
O'Kane, Francis W; McGibbon, Chris A; Krebs, David E (2003) Kinetic analysis of planned gait termination in healthy subjects and patients with balance disorders. Gait Posture 17:170-9
Krebs, David E; Gill-Body, Kathleen M; Parker, Stephen W et al. (2003) Vestibular rehabilitation: useful but not universally so. Otolaryngol Head Neck Surg 128:240-50
Seidel, Brigitta; Krebs, David E (2002) Base of support is not wider in chronic ataxic and unsteady patients. J Rehabil Med 34:288-92

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