Smoking remains the leading cause of preventable diseases and death in the US, and is known to be heritable. This application aims to develop a set of nicotine addiction cell lines based on clinically defined imaging phenotype and genotype. Our goal is to test that neuronal electrophysiological response to nicotinic agonists will be associated with the strength of the clinical imaging based circuit phenotype in patients with severe nicotine addiction and carry smoking related risk alleles. Our innovation here is to closely link these cell lines with state-of-the art clinical measures of nicotine addiction, so that we coud iteratively test electrophysiological phenotypes of the cells that are likely underlying key clinicl nicotine addiction measures.

Public Health Relevance

Smoking remains the leading cause of preventable diseases and death in the US. This application aims to develop nicotine addiction cell lines based on clinically defined imaging phenotype and genotype. Our goal is to identify electrophysiological mechanisms underlying clinical nicotine addiction.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21DA033817-02
Application #
8420444
Study Section
Special Emphasis Panel (ZDA1-SXC-E (12))
Program Officer
Lin, Yu
Project Start
2012-02-15
Project End
2015-01-31
Budget Start
2013-02-01
Budget End
2015-01-31
Support Year
2
Fiscal Year
2013
Total Cost
$184,200
Indirect Cost
$64,200
Name
University of Maryland Baltimore
Department
Psychiatry
Type
Schools of Medicine
DUNS #
188435911
City
Baltimore
State
MD
Country
United States
Zip Code
21201
Chiappelli, J; Hong, L E; Wijtenburg, S A et al. (2015) Alterations in frontal white matter neurochemistry and microstructure in schizophrenia: implications for neuroinflammation. Transl Psychiatry 5:e548
Nugent, Katie L; Chiappelli, Joshua; Rowland, Laura M et al. (2014) Distress intolerance and clinical functioning in persons with schizophrenia. Psychiatry Res 220:31-6
Chiappelli, Joshua; Pocivavsek, Ana; Nugent, Katie L et al. (2014) Stress-induced increase in kynurenic acid as a potential biomarker for patients with schizophrenia and distress intolerance. JAMA Psychiatry 71:761-8
Du, Xiaoming; Summerfelt, Ann; Chiappelli, Joshua et al. (2014) Individualized brain inhibition and excitation profile in response to paired-pulse TMS. J Mot Behav 46:39-48
Wright, Susan; Kochunov, Peter; Chiappelli, Joshua et al. (2014) Accelerated white matter aging in schizophrenia: role of white matter blood perfusion. Neurobiol Aging 35:2411-2418
Moran, Lauren V; Sampath, Hemalatha; Kochunov, Peter et al. (2013) Brain circuits that link schizophrenia to high risk of cigarette smoking. Schizophr Bull 39:1373-81
Moran, Lauren V; Tagamets, Malle A; Sampath, Hemalatha et al. (2013) Disruption of anterior insula modulation of large-scale brain networks in schizophrenia. Biol Psychiatry 74:467-74
Ballesteros, Alejandro; Summerfelt, Ann; Du, Xiaoming et al. (2013) Electrophysiological intermediate biomarkers for oxidative stress in schizophrenia. Clin Neurophysiol 124:2209-15
Ballesteros, Alejandro; Jiang, Pan; Summerfelt, Ann et al. (2013) No evidence of exogenous origin for the abnormal glutathione redox state in schizophrenia. Schizophr Res 146:184-9
Moran, Lauren V; Sampath, Hemalatha; Stein, Elliot A et al. (2012) Insular and anterior cingulate circuits in smokers with schizophrenia. Schizophr Res 142:223-9

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