Smoking remains the leading cause of preventable diseases and death in the US, and is known to be heritable. This application aims to develop a set of nicotine addiction cell lines based on clinically defined imaging phenotype and genotype. Our goal is to test that neuronal electrophysiological response to nicotinic agonists will be associated with the strength of the clinical imaging based circuit phenotype in patients with severe nicotine addiction and carry smoking related risk alleles. Our innovation here is to closely link these cell lines with state-of-the art clinical measures of nicotine addiction, so that we coud iteratively test electrophysiological phenotypes of the cells that are likely underlying key clinicl nicotine addiction measures.
Smoking remains the leading cause of preventable diseases and death in the US. This application aims to develop nicotine addiction cell lines based on clinically defined imaging phenotype and genotype. Our goal is to identify electrophysiological mechanisms underlying clinical nicotine addiction.
|Chiappelli, J; Hong, L E; Wijtenburg, S A et al. (2015) Alterations in frontal white matter neurochemistry and microstructure in schizophrenia: implications for neuroinflammation. Transl Psychiatry 5:e548|
|Wright, Susan N; Kochunov, Peter; Chiappelli, Joshua et al. (2014) Accelerated white matter aging in schizophrenia: role of white matter blood perfusion. Neurobiol Aging 35:2411-8|
|Du, Xiaoming; Summerfelt, Ann; Chiappelli, Joshua et al. (2014) Individualized brain inhibition and excitation profile in response to paired-pulse TMS. J Mot Behav 46:39-48|
|Nugent, Katie L; Chiappelli, Joshua; Rowland, Laura M et al. (2014) Distress intolerance and clinical functioning in persons with schizophrenia. Psychiatry Res 220:31-6|
|Chiappelli, Joshua; Pocivavsek, Ana; Nugent, Katie L et al. (2014) Stress-induced increase in kynurenic acid as a potential biomarker for patients with schizophrenia and distress intolerance. JAMA Psychiatry 71:761-8|
|Moran, Lauren V; Sampath, Hemalatha; Kochunov, Peter et al. (2013) Brain circuits that link schizophrenia to high risk of cigarette smoking. Schizophr Bull 39:1373-81|
|Moran, Lauren V; Tagamets, Malle A; Sampath, Hemalatha et al. (2013) Disruption of anterior insula modulation of large-scale brain networks in schizophrenia. Biol Psychiatry 74:467-74|
|Ballesteros, Alejandro; Jiang, Pan; Summerfelt, Ann et al. (2013) No evidence of exogenous origin for the abnormal glutathione redox state in schizophrenia. Schizophr Res 146:184-9|
|Ballesteros, Alejandro; Summerfelt, Ann; Du, Xiaoming et al. (2013) Electrophysiological intermediate biomarkers for oxidative stress in schizophrenia. Clin Neurophysiol 124:2209-15|
|Moran, Lauren V; Sampath, Hemalatha; Stein, Elliot A et al. (2012) Insular and anterior cingulate circuits in smokers with schizophrenia. Schizophr Res 142:223-9|
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