Ultrasound imaging is a low-cost, safe and mobile imaging modality, which explains in part its widespread use in clinical Radiology. Although 2D anatomical ultrasound imaging appears very fast, generating images as fast as the eye can see them, frame rates can be severely degraded for more elaborate scans. During the resection and/or ablation of liver lesions, visualizing the tumor(s) in relation to the 3D vasculature in real- time would be highly desirable, increasing the odds of removing/ablating all tumor tissues while sparing important vessels. But the acquisition of large amounts of 3D information would normally degrade frame rates to levels unacceptable for image guidance. We propose a combination of spatial and temporal encoding schemes capable of accelerating by several-fold the acquisition rate of ultrasound images, allowing elaborate ultrasound images to be obtained at high frame rates. The anatomy of interest is probed in multiple directions at a time using multiple superposed beams, reducing imaging time by several-fold compared to conventional acquisitions where the object is probed in a single direction at a time. Based on the raw signal received from all overlapped beams, signals from individual beams can be recovered at the reconstruction stage using our proposed spatial and temporal algorithms. Preliminary results from simulated and experimental acoustic phantoms were obtained where imaging speed was increased by up to 32-fold.

Public Health Relevance

Ultrasound imaging is a particularly widespread medical imaging modality, due in part to its safety and low cost. Because it is fast, generating images as fast as the human eye can see them, ultrasound imaging is often used to guide procedures, such as liver resections and tumor ablations. More elaborate ultrasound images, where tumor(s) could be seen in 3D in conjunction to the vascular bed, would be helpful toward safely removing all lesions and preserving important vessels but would lead to unacceptably low frame rates. The present project proposes an approach to speed-up by several-fold the image acquisition process in ultrasound imaging, enabling 3D and vascular information to be obtained with high frame rates. Preliminary results were obtained where imaging speed was increased by up to 32-fold.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Exploratory/Developmental Grants (R21)
Project #
1R21EB009503-01A1
Application #
7895321
Study Section
Special Emphasis Panel (ZRG1-SBIB-S (91))
Program Officer
Lopez, Hector
Project Start
2010-04-01
Project End
2012-03-31
Budget Start
2010-04-01
Budget End
2011-03-31
Support Year
1
Fiscal Year
2010
Total Cost
$267,000
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
Madore, Bruno; Chiou, Jr-yuan George; Chu, Renxin et al. (2014) Accelerated multi-shot diffusion imaging. Magn Reson Med 72:324-36
Madore, Bruno; Meral, F Can (2012) Reconstruction algorithm for improved ultrasound image quality. IEEE Trans Ultrason Ferroelectr Freq Control 59:217-30
Madore, Bruno; Panych, Lawrence P; Mei, Chang-Sheng et al. (2011) Multipathway sequences for MR thermometry. Magn Reson Med 66:658-68
Mei, Chang-Sheng; Panych, Lawrence P; Yuan, Jing et al. (2011) Combining two-dimensional spatially selective RF excitation, parallel imaging, and UNFOLD for accelerated MR thermometry imaging. Magn Reson Med 66:112-22
Ababneh, Riad; Yuan, Jing; Madore, Bruno (2010) Fat-water separation in dynamic objects using an UNFOLD-like temporal processing. J Magn Reson Imaging 32:962-70
Madore, Bruno; White, P Jason; Thomenius, Kai et al. (2009) Accelerated focused ultrasound imaging. IEEE Trans Ultrason Ferroelectr Freq Control 56:2612-23