Cancer is the second leading cause of death among children, but little is known on the etiology of childhood cancers. The majority of previous attempts to link childhood cancer to pesticides have relied upon parental interview or sources such as birth or death records, making results potentially subject to biases of recall or information, and few studies have had adequate power to study specific cancer subtypes or had an exposure assessment that was able to assess exposures to specific pesticides. We propose a large case-control study of California children diagnosed with certain cancers (acute myeloid leukemia, acute lymphoblastic leukemia, non Hodgkin lymphoma, astrocytoma, primitive neuroectodermal tumors, Wilms tumor, soft tissue sarcomas) and population-based controls. Cases and controls will be taken from the ongoing population-based Air Pollution and Childhood Cancers (APCC) study, in which we linked cancer cases, identified from the California Cancer Registry to birth certificates and selected controls at random from California birth records. The proposed study will include approximately 9000 cases and 90000 controls. Exposure to pesticides will be assessed using our geographic pesticide exposure assessment tool (GRAPES) that utilizes the unique California Pesticide Use Report system, in combination with agricultural land-use maps, to derive record-based estimates of residential exposures to specific pesticides. The GRAPES system will estimate trimester-specific pregnancy and early childhood (<1 year of age) exposures to pesticides, allowing us to identify critical time windows of exposure to toxins in gestational development. Our focus will be the carcinogenic effects of 23 agents which have been identified as likely or probable carcinogens by the US EPA and which are among the most commonly applied pesticides in California. This proposal presents an exciting opportunity to identify specific cancer-pesticide links, with the possibility of informing policy on pesticide regulation and encouraging research on therapeutic and preventive strategies.

Public Health Relevance

This project proposes to evaluate the carcinogenicity of specific pesticides in relation to certain childhood cancers. We will determine pesticide exposures using our geographic pesticide exposure assessment tool (GRAPES) that integrates pesticide application information from the unique California Pesticide Use Report system with agricultural land-use maps, to pinpoint residential exposures to specific pesticides.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21ES019986-02
Application #
8245768
Study Section
Epidemiology of Cancer Study Section (EPIC)
Program Officer
Lawler, Cindy P
Project Start
2011-04-01
Project End
2014-03-31
Budget Start
2012-04-01
Budget End
2014-03-31
Support Year
2
Fiscal Year
2012
Total Cost
$185,223
Indirect Cost
$60,223
Name
University of California Los Angeles
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Contreras, Zuelma A; Ritz, Beate; Virk, Jasveer et al. (2016) Maternal pre-pregnancy and gestational diabetes, obesity, gestational weight gain, and risk of cancer in young children: a population-based study in California. Cancer Causes Control 27:1273-85
Azary, Saeedeh; Ganguly, Arupa; Bunin, Greta R et al. (2016) Sporadic Retinoblastoma and Parental Smoking and Alcohol Consumption before and after Conception: A Report from the Children's Oncology Group. PLoS One 11:e0151728
Heck, Julia E; Contreras, Zuelma A; Park, Andrew S et al. (2016) Smoking in pregnancy and risk of cancer among young children: A population-based study. Int J Cancer 139:613-6
Heck, Julia E; Park, Andrew S; Contreras, Zuelma A et al. (2016) Risk of Childhood Cancer by Maternal Birthplace: A Test of the Hispanic Paradox. JAMA Pediatr 170:585-92
von Ehrenstein, Ondine S; Heck, Julia E; Park, Andrew S et al. (2016) In Utero and Early-Life Exposure to Ambient Air Toxics and Childhood Brain Tumors: A Population-Based Case-Control Study in California, USA. Environ Health Perspect 124:1093-9
Woehrer, Adelheid; Lau, Ching C; Prayer, Daniela et al. (2015) Brain Tumor Epidemiology - A Hub within Multidisciplinary Neuro-oncology. Report on the 15th Brain Tumor Epidemiology Consortium (BTEC) Annual Meeting, Vienna, 2014. Clin Neuropathol 34:40-6
Lombardi, Christina; Ganguly, Arupa; Bunin, Greta R et al. (2015) Maternal diet during pregnancy and unilateral retinoblastoma. Cancer Causes Control 26:387-97
Heck, Julia E; Park, Andrew S; Qiu, Jiaheng et al. (2015) Retinoblastoma and ambient exposure to air toxics in the perinatal period. J Expo Sci Environ Epidemiol 25:182-6
Marcotte, Erin L; Ritz, Beate; Cockburn, Myles et al. (2014) Exposure to infections and risk of leukemia in young children. Cancer Epidemiol Biomarkers Prev 23:1195-203
Shrestha, Anshu; Ritz, Beate; Wilhelm, Michelle et al. (2014) Prenatal exposure to air toxics and risk of Wilms' tumor in 0- to 5-year-old children. J Occup Environ Med 56:573-8

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