There is a growing body of evidence that exposure to poly- and perfluoroalkyl substances (PFASs), such as perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA), adversely affect health. Water samples from private wells and public water systems collected southeast of Colorado Springs in the towns of Fountain, Widefield, and Security (FWS) detected a wide range of PFASs, including high levels of perfluorohexane sulfonate (PFHxS). It is likely that PFHxS and related compounds migrated offsite from local airfields and made their way into the public and private groundwater wells as well as into the FWS municipal water systems. The recent discovery of this contamination and the beginning of intervention efforts provides an opportunity to assess these impacts of these highly persistent PFASs at or near the peak serum levels of these compounds due to long-term exposure to high levels. We seek time-sensitive funding to characterize serum levels, explore their potential links to biomarkers of effect, and estimate the half-life in the body of PFHxS and related compounds. Our design will collect exposure information and biomarkers in participants to test the hypothesis that the FWS population exposure is associated with biomarkers of liver function, immunotoxicity, and inflammation. We will measure serum PFAS one time in 200 residents and relate this exposure to these biomarkers of effect; a second round of blood and water sampling will be used to explore persistence and the impact of intervention on drinking water levels and body burden. These biomarkers of effect were chosen based on an analysis of biologic pathways that link PFAS exposure to changes in liver function and immune effects and subsequent adverse health outcomes. By collecting baseline measurements and prospectively following 50 participants in the second year this project will develop data, tools and community networks needed to design and facilitate subsequent prospective studies that will provide insight on the health effects associated with ubiquitous PFAS exposure.

Public Health Relevance

There is a growing body of evidence that exposure to poly- and perfluoroalkyl substances (PFASs) can adversely affect health. Contamination of ground and surface water around Fountain, Security, and Widefield, CO has resulted in prolonged exposure to high levels of these pollutants in approximately 80,000 people. Since nearly all US residents are exposed to these compounds and because even small changes in health may lead to a considerable public health impact over time, this study is important because it will generate knowledge to help understand the magnitude of human health impacts associated with PFAS exposure.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21ES029394-02
Application #
9613817
Study Section
Special Emphasis Panel (ZES1)
Program Officer
Boyles, Abee
Project Start
2018-01-01
Project End
2019-12-31
Budget Start
2019-01-01
Budget End
2019-12-31
Support Year
2
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045