We propose to develop an SDOCT surgical microscope system for detection, processing, and presentation of digital images to the surgeon. The current surgeon's view of the retina through a binocular microscope is limited by the ability of the human eye to resolve fine structures during surgery and by the ability of the human visual system to estimate depth from a stereoscopic view of the eye. The SDOCT output with improved resolution of intraocular structures in cross section will be provided to the surgeon in real time through a heads-up display that is compatible with current surgical viewing methods. Image processing algorithms will be developed to evaluate fundus video and SDOCT image parameters to provide real-time feedback to the surgeon regarding the relative position of retinal structures and surgical instruments, and also to control adaptive sampling of the SDOCT image data in critical regions.
The specific aims of the project are to: (1) Adapt state-of-the-art high-speed SDOCT technology for intraoperative use in vitreoretinal surgery;(2) Apply new image processing concepts to develop an adaptive framework for real-time SDOCT imaging and analysis with applications in vitreoretinal surgery;and (3) Integrate surgical needs with SDOCT technology for intraoperative use, test and provide feedback on the intraoperative system both in laboratory and then in the operating room.

Public Health Relevance

We propose to develop an improved surgical microscope system using spectral domain optical coherence tomography technology for detection, processing, and presentation of digital images to the surgeon. The digital output with improved resolution of intraocular structures in cross section will be provided to the surgeon in real time through a heads-up display that is compatible with current surgical viewing methods.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Exploratory/Developmental Grants (R21)
Project #
1R21EY019411-01A1
Application #
7740278
Study Section
Special Emphasis Panel (ZRG1-ETTN-R (92))
Program Officer
Mariani, Andrew P
Project Start
2009-09-01
Project End
2011-08-31
Budget Start
2009-09-01
Budget End
2010-08-31
Support Year
1
Fiscal Year
2009
Total Cost
$224,368
Indirect Cost
Name
Duke University
Department
Biomedical Engineering
Type
Schools of Engineering
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Shen, Liangbo; Carrasco-Zevallos, Oscar; Keller, Brenton et al. (2016) Novel microscope-integrated stereoscopic heads-up display for intrasurgical optical coherence tomography. Biomed Opt Express 7:1711-26
Hahn, Paul; Carrasco-Zevallos, Oscar; Cunefare, David et al. (2015) Intrasurgical Human Retinal Imaging With Manual Instrument Tracking Using a Microscope-Integrated Spectral-Domain Optical Coherence Tomography Device. Transl Vis Sci Technol 4:1
Nankivil, Derek; Dhalla, Al-Hafeez; Gahm, Niklas et al. (2014) Coherence revival multiplexed, buffered swept source optical coherence tomography: 400 kHz imaging with a 100 kHz source. Opt Lett 39:3740-3
Hahn, Paul; Migacz, Justin; O'Donnell, Rachelle et al. (2013) Preclinical evaluation and intraoperative human retinal imaging with a high-resolution microscope-integrated spectral domain optical coherence tomography device. Retina 33:1328-37
Hahn, Paul; Migacz, Justin; O'Connell, Rachelle et al. (2013) Unprocessed real-time imaging of vitreoretinal surgical maneuvers using a microscope-integrated spectral-domain optical coherence tomography system. Graefes Arch Clin Exp Ophthalmol 251:213-20
LaRocca, Francesco; Dhalla, Al-Hafeez; Kelly, Michael P et al. (2013) Optimization of confocal scanning laser ophthalmoscope design. J Biomed Opt 18:076015
Ehlers, Justis P; Tao, Yuankai K; Farsiu, Sina et al. (2013) Visualization of real-time intraoperative maneuvers with a microscope-mounted spectral domain optical coherence tomography system. Retina 33:232-6
Dhalla, Al-Hafeez; Nankivil, Derek; Bustamante, Theresa et al. (2012) Simultaneous swept source optical coherence tomography of the anterior segment and retina using coherence revival. Opt Lett 37:1883-5
Ehlers, Justis P; Kernstine, Kendal; Farsiu, Sina et al. (2011) Analysis of pars plana vitrectomy for optic pit-related maculopathy with intraoperative optical coherence tomography: a possible connection with the vitreous cavity. Arch Ophthalmol 129:1483-6
Ehlers, Justis P; Tao, Yuankai K; Farsiu, Sina et al. (2011) Integration of a spectral domain optical coherence tomography system into a surgical microscope for intraoperative imaging. Invest Ophthalmol Vis Sci 52:3153-9

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