Quantitative magnetic resonance imaging (qMRI) methods provide standardizable and objective measures for characterizing brain development and abnormalities in young children. However, motion is a significant problem for applying extended qMRI studies in young children and has limited the ability to perform studies in these populations. This project will further develop, optimize and evaluate technologies for multicomponent relaxometry. The technique will be specifically optimized for pediatric imaging by dramatically reducing the acquisition time and utilizing a novel image reconstruction method that reduces motion artifacts. These optimized imaging technologies will be evaluated in young children. This project will provide a set of protocols, software tools, and strategies for investigating healthy and abnormal brain development in both clinical and research pediatric populations.

Public Health Relevance

This project will develop and optimize novel MRI (magnetic resonance imaging) methods for quantitative neuroimaging studies in awake young children, which will improve the success rates of the imaging methods in younger and more intellectually disabled children without sedation. These techniques are targeted towards reducing imaging times and correcting the effects of head motion. These improvements will enable neuroimaging studies young healthy children as well as pediatric patients with neurological, genetic, and developmental disorders, as well as brain injuries.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Exploratory/Developmental Grants (R21)
Project #
1R21HD078119-01A1
Application #
8824114
Study Section
Special Emphasis Panel (ZRG1-SBIB-V (82))
Program Officer
Freund, Lisa S
Project Start
2014-09-22
Project End
2016-07-31
Budget Start
2014-09-22
Budget End
2015-07-31
Support Year
1
Fiscal Year
2014
Total Cost
$221,710
Indirect Cost
$71,710
Name
University of Wisconsin Madison
Department
Physics
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715